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http://dx.doi.org/10.5352/JLS.2003.13.5.626

Effects of Bromate on the Glutathione Synthesis in Various Organs of Rats  

김나영 (경성대학교 환경문제연구소)
강혜옥 (경성대학교 환경문제연구소)
이무강 (경성대학교 환경문제연구소)
최종원 (경성대학교 환경문제연구소)
Publication Information
Journal of Life Science / v.13, no.5, 2003 , pp. 626-633 More about this Journal
Abstract
The effects of bromate administration on glutathione were studied in rats. The contents of glutathione in the liver and kidney were significantly decreased but the alteration was not significant in lung and blood by bromate adminstration. The decrease occurred without concomitant increases in oxidized glutathione (GSSG) or in the GSSG/GSH＋GSSG ratio. The activities of $\gamma-glutamyl$ cysteine synthetase in the liver and kidney were decreased by bromate administration. $\gamma-Glutamyl$ transpeptidase activities was significantly decreased in the kidney and not significantly decreased in the lung of bromate treated-rats. These results suggest that the decreased synthesis of glutathione by bromate may be an important reason for the decreased level of glutathione in the liver and kidney, thus the decreased glutathione transport would be a factor on the changes of glutathione contents in bromate-treated rats.
Keywords
Bromate; glutathione content; ${\gamma}$-glutamyl transpeptidase; oxidized glutathione; ${\gamma}$-glutamylcysteine synthetase;
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