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http://dx.doi.org/10.5762/KAIS.2021.22.6.341

Clinical Significance of Serum Amylase Measurement in Sjögren's Syndrome  

Nam, Eon Jeong (Department of Internal Medicine, School of Medicine, Kyungpook National University)
Lee, Nan Young (Department of Clinical Pathology, School of Medicine, Kyungpook National University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.22, no.6, 2021 , pp. 341-348 More about this Journal
Abstract
Serum amylase is a representative enzyme secreted by the salivary gland and pancreas. This study investigates the clinical significance of serum amylase levels in Sjögren's syndrome (SS). Totally, 70 female subjects were enrolled, who were diagnosed as SS and had no accompanying afflictions that affected the serum amylase levels. Unstimulated salivary flow rate (U-SFR) and stimulated SFR (S-SFR), salivary gland scan, and disease activity markers (ESSDAI and ESSPRI), as well as blood tests including ESR, CRP, and amylase, were evaluated. Serum amylase showed significant positive correlation with the U-SFR and S-SFR, and was increased with higher ejection fraction (EF) of the parotid gland. However, there was no significant correlation with disease activity and inflammatory markers. Based on their average amylase levels, subjects were divided into two groups. The group with higher serum amylase levels showed a statistically significant increase in the S-SFR and EF of the parotid gland. Considering the results of the salivary gland scan, we conclude that serum amylase is significantly correlated with SFR and the EF of the parotid gland, thereby indicating that the salivary gland function remains intact in SS.
Keywords
Serum Amylase; Salivary Gland; Sjogren's Syndrome; Salivary Flow Rate; Ejection Fraction; Parotid Gland;
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