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http://dx.doi.org/10.5762/KAIS.2021.22.6.108

Effect of fludrocortisone in cervical spinal cord injury patients with orthostatic hypotension - randomized controlled trial  

Lee, Do-Hee (Department of Rehabilitation Medicine, Wonkwang University School of Medicine)
Joo, Min-Cheol (Department of Rehabilitation Medicine, Wonkwang University School of Medicine)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.22, no.6, 2021 , pp. 108-115 More about this Journal
Abstract
The purpose of this study was to investigate the therapeutic effect of fludrocortisone in patients suffering from cervical spinal cord injury (SCI) with orthostatic hypotension (OH). Twenty-six patients with cervical SCI diagnosed with OH through a head-up tilt test were randomly assigned, and they were given either conservative treatment or additional fludrocortisone treatment. Fludrocortisone was administered for 2 weeks, increasing from 0.1 mg to 0.2 mg week . Blood pressure (BP), heart rate (HR), and blood parameters were measured at the beginning and after 2 weeks. After 2 weeks of treatment, there was a significant increase in the baseline BP of the treatment groups (p<.05). When analyzing the drop ratio, there was a tendency for a lower orthostatic BP drop in the treatment groups. Mild adverse events were reported in 7.69% of the treatment groups. Fludrocortisone exhibited therapeutic effects such as preventing cardiovascular complications and continuing rehabilitation through increased baseline BP and reduced OH, and can therefore be considered as a treatment option for OH in patients with SCI.
Keywords
Spinal Cord Injury; Quadriplegia; Orthostatic Hypotension; Fludrocortisone; Rehabilitation;
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