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http://dx.doi.org/10.5762/KAIS.2020.21.10.231

The Effects of Gobonyangjeonbang Administration on Antioxidative of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced Rats.  

Yang, Dong Hyun (Department of Biomedical Laboratory Science, Daejeon University)
OH, Ji Hye (Department of Biomedical Laboratory Science, Daejeon University)
Park, Un kyu (Department of Biomedical Laboratory Science, Daejeon University)
Cho, Chung Sik (Department of Korean Medicine, Daejeon University)
Hwang, Seock Yeon (Department of Biomedical Laboratory Science, Daejeon University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.21, no.10, 2020 , pp. 231-239 More about this Journal
Abstract
The purpose of this study was to evaluate the effects of gobonyangjeonbang (GYB) on the endocrine function and the antioxidant efficacy of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in rats. In 2017, to evaluate the efficacy of GYB on oxidative stress, 35 male SD rats were divided into five groups and tested. The normal control group was administered saline as a vehicle, while the TCDD-alone group was administered TCDD (2 ㎍/kg per week) intraperitoneally and with physiological saline, and the test group was administered GYB orally by dividing it into three concentrations (75, 150, and 300 mg/kg) for six weeks. Bodyweight decreased significantly after six weeks of TCDD exposure, when compared to rats in the NC group (p<0.001). However, weight loss from TCDD was significantly protected by administration of GYB at 300 mg/kg (p<0.01). The rat liver induced by TCDD showed cytoplasmic vacuole degeneration, and the hepatic sinusoid and weight increased. As a result of measuring MDA and SOD, both items tended to decrease under TCDD administration. On the other hand, there was no change due to GYB administration, and significance was observed in the GYB 300 mg/kg group compared to the NC group in the SOD result (p<0.05). These findings demonstrated that GYB may have a protective effect against TCDD-induced liver toxicity in rats.
Keywords
Antioxidant; Gobonyangjeonbang (GYB); Hepatotoxicity; SOD; TCDD;
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Times Cited By KSCI : 6  (Citation Analysis)
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