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http://dx.doi.org/10.5762/KAIS.2017.18.3.513

Evaluation of the cosmeceutical activity of ethanol extracts from Perilla frutescens var. acuta  

Park, Do-Young (Interdisciplinary Program of Perfume and Cosmetics,Graduate School of Chonnam National University)
Lee, Ki-Young (Interdisciplinary Program of Perfume and Cosmetics,Graduate School of Chonnam National University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.18, no.3, 2017 , pp. 513-517 More about this Journal
Abstract
The purpose of this study was to investigate the antioxidative and anti-inflammatory activities of ethanol extracts from Perilla frutescens var. acuta by varying the concentration of ethanol at 30, 50, 70, and 90% to utilize the effective extract of Perilla frutescens as a cosmetic and pharmaceutical material. In the DPPH antioxidant activity test, the 70% ethanol extract showed the highest activity with an IC50 of 680.98ppm. ABTS showed a high activity in the 50% ethanol extract and the 70% ethanol extract with an IC50 of 646.94 and 661.94 ppm, respectively. Each ethanol extract showed antioxidant activity at a certain concentration (100-10000 ppm), but did not show any significant relationship with the ethanol extract concentration. In RAW 264.7 macrophages induced by LPS, each of the ethanol extracts showed reduced NO production in all extracts, and more than 50% ethanol extract (10000ppm) inhibited nitric oxide formation by 85% or more. In particular, the 70% ethanol extract showed 90% or more nitric oxide production inhibition. In addition, the MTT assay showed no cytotoxicity at all concentrations (1250-10000 ppm) of each extract. In this study, the ethanol extract of Perilla frutescens var. acuta has antioxidant activity and anti-inflammatory activity that is dependent on the concentration at each extraction concentration.
Keywords
anti-inflammatory; antioxidant; cosmeceutical; Perilla frutescens var. acuta; Perilla frutescens var. crispa;
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