Telomere-Mitochondrion Links Contribute to Induction of Senescence in MCF-7 Cells after Carbon-Ion Irradiation |
Miao, Guo-Ying
(Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences)
Zhou, Xin (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Zhang, Xin (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Xie, Yi (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Sun, Chao (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Liu, Yang (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Gan, Lu (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) Zhang, Hong (Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences) |
1 | Ahmed S, Passos J F, Birket M J, et al (2008). Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress, J Cell Sci, 121, 1046-53. DOI |
2 | Bhalla K, Hwang BJ, Dewi RE, et al (2011). PGC1alpha promotes tumor growth by inducing gene expression programs supporting lipogenesis. Cancer Res, 71, 6888-98 DOI |
3 | Buchner N, Zschauer TC, Lukosz M, Altschmied J, Haendeler J (2010). Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent. Experimental Gerontol, 45, 558-62. DOI |
4 | David R (2011). Ageing: Mitochondria and telomeres come together Nature reviews. Molecular Cell Biol, 12, 204. |
5 | Durante M, George K and Cucinotta EA (2006). Chromosomes lacking telomeres are present in the progeny of human lymphocytes exposed to heavy ions. Radiat Res, 165, 51-8. DOI |
6 | Gordon DM, Santos JH (2010). The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism. J Nucleic Acids, 2010. |
7 | Haendeler J, Drose S, Buchner N, et al (2009). Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol, 29, 929-35. DOI |
8 | Indran IR, Hande MP, Pervaiz S (2011). hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res, 71, 266-76. |
9 | Jakel O, Karger CP, Debus J (2008). The future of heavy ion radiotherapy. Medical Physics, 35, 5653-63. DOI |
10 | Jinno-Oue A, Shimizu N, Hamada N, et al (2010). Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human glioma-derived cell line Int J Radiat Oncol Biol Phys, 76, 229-41. DOI |
11 | Lee YH, Kang BS, Bae YS (2014). Premature senescence in human breast cancer and colon cancer cells by tamoxifenmediated reactive oxygen species generation. Life Sci, 97, 116-22. DOI |
12 | Li YB, Gao JL, Zhong ZF, et al (2013). Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways Pharmacological Reports, 65, 700-9. DOI |
13 | Liu L, Trimarchi JR, Smith PJ, Keefe DL (2002). Mitochondrial dysfunction leads to telomere attrition and genomic instability. Aging Cell, 1, 40-6. DOI |
14 | Martinez-Outschoorn UE, Goldberg A, Lin Z, et al (2011a). Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biol Ther, 12, 924-38. DOI |
15 | Martinez-Outschoorn UE, Lin Z, Ko YH, et al (2011b). Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells Cell Cycle, 10, 2521-8. DOI |
16 | Sahin E, Colla S, Liesa M, et al (2011). Telomere dysfunction induces metabolic and mitochondrial compromise. Nature, 470, 359-65. DOI |
17 | Saretzki G (2009). Telomerase, mitochondria and oxidative stress.Experimental Gerontol, 44, 485-92. DOI |
18 | Santos JH, Meyer JN, Mandavilli BS, Van Houten B (2006a). Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol, 314, 183-99. DOI |
19 | Santos JH, Meyer JN, Skorvaga M, Annab LA, Van Houten B (2004). Mitochondrial hTERT exacerbates free-radicalmediated mtDNA damage. Aging Cell, 3, 399-411. DOI |
20 | Santos JH, Meyer JN, Van Houten B (2006b). Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet, 15, 1757-68. DOI |
21 | Sharma NK, Reyes A, Green P, et al (2012). Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res, 40, 712-25. DOI |
22 | Wan XS, Zhou Z, Ware JH, Kennedy AR (2005). Standardization of a fluorometric assay for measuring oxidative stress in irradiated cells. Radiation Res, 163, 232-40. DOI |
23 | Wenz T (2013) Regulation of mitochondrial biogenesis and PGC- 1 alpha under cellular stress. Mitochondrion, 13, 134-42. DOI |
24 | Yan J, Zhou Y, Chen D, et al (2015). Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells. J Cancer, 6, 151-9. DOI |
25 | Zhou X, Liu X, Zhang X, et al (2012). Non-randomized mtDNA damage after ionizing radiation via charge transport. Sci Rep, 2, 780. DOI |
26 | Zhou X, Zhang X, Xie Y, et al (2013). DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption. PLoS One, 8, 72641. DOI |