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http://dx.doi.org/10.7314/APJCP.2016.17.3.917

Helicobacter pylori Infection and Dietary Factors Act Synergistically to Promote Gastric Cancer  

Raei, Negin (Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili)
Behrouz, Bahador (Department of Microbiology, School of Medicine, Tehran University of Medical Sciences)
Zahri, Saber (Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili)
Latifi-Navid, Saeid (Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.3, 2016 , pp. 917-921 More about this Journal
Abstract
However, the incidence of gastric cancer (GC) has been decreased in past decades; GC is the second cause of cancer related death in the world. Evidence has illustrated that several factors including Helicobacter pylori (H. pylori) infection, host genetics, and environmental factors (smoking and particularly diet) may play a crucial role in gastric carcinogenesis. It has been demonstrated that high consumption of fresh fruits, vegetables, high level of selenium and zinc in drinking water, sufficient iron, and cholesterol protect against GC, while; smoked, pickled, and preserved foods in salt, and nitrites increase the risk of GC. Epidemiological studies have also proved that H. pylori infection and a high salt diet could independently induce atrophic gastritis and intestinal metaplasia. Recently, studies have been demonstrated that dietary factors directly influence H. pylori virulence. The use of appropriate diet could reduce levels of H. pylori colonization or virulence and prevent or delay development of peptic ulcers or gastric carcinoma. This is attractive from a number of perspectives including those of cost, treatment tolerability, and cultural acceptability. This review will describe new insights into the pathogenesis of H. pylori in relation to environmental factors, especially dietary, not only to find the developed means for preventing and treating GC, but also for understanding the role of chronic inflammation in the development of other malignancies.
Keywords
Helicobacter pylori; dietary factors; gastric cancer;
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1 van Lee L, Heyworth J, McNaughton S, et al (2011). Selected dietary micronutrients and the risk of right- and left-sided colorectal cancers: a case-control study in Western Australia. Ann Epidemiol, 21, 170-7.   DOI
2 Wang XQ, Terry PD, Yan H (2009). Review of salt consumption and stomach cancer risk: epidemiological and biological evidence. World J Gastroenterol, 15, 2204-13.   DOI
3 Waring AJ, Drake IM, Schorah CJ, et al (1996). Ascorbic acid and total vitamin C concentrations in plasma, gastric juice, and gastrointestinal mucosa: effects of gastritis and oral supplementation. Gut, 38, 171-6.   DOI
4 Winter JA, Letley DP, Cook KW, et al (2014). A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach. J Infect Dis, 210, 954-63.   DOI
5 Wiseman M (2008). The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc, 67, 253-6.   DOI
6 Woodward M, Morrison C, McColl K (2000). An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol, 53, 175-81.   DOI
7 Wu X, Chen VW, Andrews PA, et al (2007). Incidence of esophageal and gastric cancers among Hispanics, non-Hispanic whites and non-Hispanic blacks in the United States: subsite and histology differences. Cancer Causes Control, 18, 585-93.   DOI
8 Wunder C, Churin Y, Winau F, et al (2006). Cholesterol glucosylation promotes immune evasion by Helicobacter pylori. Nat Med, 12, 1030-8.   DOI
9 Yamaguchi N, Kakizoe T (2001). Synergistic interaction between Helicobacter pylori gastritis and diet in gastric cancer. Lancet Oncol, 2, 88-94.   DOI
10 Yip R, Limburg PJ, Ahlquist DA, et al (1997). Pervasive occult gastrointestinal bleeding in an Alaska native population with prevalent iron deficiency. Role of Helicobacter pylori gastritis. JAMA, 277, 1135-9.   DOI
11 You WC, Blot WJ, Chang YS, et al (1988). Diet and high risk of stomach cancer in Shandong, China. Cancer Res, 48, 3518-23.
12 Boquet P, Ricci V (2012). Intoxication strategy of Helicobacter pylori VacA toxin. Trends Microbiol, 20, 165-74.   DOI
13 Akopyants NS, Clifton SW, Kersulyte D, et al (1998). Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol, 28, 37-53.
14 Amieva MR, Vogelmann R, Covacci A, et al (2003). Disruption of the epithelial apical-junctional complex by Helicobacter pylori cagA. Science, 300, 1430-4.   DOI
15 Auvinen A, Salonen L, Pekkanen J, et al (2005). Radon and other natural radionuclides in drinking water and risk of stomach cancer: a case-cohort study in Finland. Int J Cancer, 114, 109-13.   DOI
16 Babaei M, Pourfarzi F, Yazdanbod A, et al (2010). Gastric cancer in Ardabil, Iran-a review and update on cancer registry data. Asian Pac J Cancer Prev, 11, 595-9.
17 Blaser MJ, Berg DE (2001). Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest, 107, 767-73.   DOI
18 Brenner H, Rothenbacher D, Arndt V (2009). Epidemiology of stomach cancer. Methods Mol Biol, 472, 467-77.   DOI
19 Camargo MC, Lazcano-Ponce E, Torres J, et al (2004). Determinants of Helicobacter pylori seroprevalence in Mexican adolescents. Helicobacter, 9, 106-14.   DOI
20 Correa P (1992). Human gastric carcinogenesis: a multistep and multifactorial process--first american cancer society award lecture on cancer epidemiology and prevention. Cancer Res, 52, 6735-40.
21 Correa P (2013). Gastric cancer: overview. Gastroenterol Clin North Am, 42, 211-7.   DOI
22 Cover TL, Blanke SR (2005). Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat Rev Microbiol, 3, 320-32.   DOI
23 Cover TL, Krishna US, Israel DA, et al (2003). Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res, 63, 951-7.
24 Cover TL, Peek RM, Jr. (2013). Diet, microbial virulence, and Helicobacter pylori-induced gastric cancer. Gut Microbes, 4, 482-93.   DOI
25 D'Elia L, Rossi G, Ippolito R, et al (2012). Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr, 31, 489-98.   DOI
26 Epplein M, Nomura AM, Hankin JH, et al (2008). Association of Helicobacter pylori infection and diet on the risk of gastric cancer: a case-control study in Hawaii. Cancer Causes Control, 19, 869-77.   DOI
27 de Martel C, Ferlay J, Franceschi S, et al (2012). Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol, 13, 607-15.   DOI
28 Derakhshan MH, Malekzadeh R, Watabe H, et al (2008). Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut, 57, 298-305.   DOI
29 Duell EJ, Travier N, Lujan-Barroso L, et al (2011). Alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Am J Clin Nutr, 94, 1266-75.   DOI
30 Epplein M, Zheng W, Li H, et al (2014). Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer, 66, 550-7.   DOI
31 Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al (2013). Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer, 49, 1374-403.   DOI
32 Ferreira RM, Machado JC, Letley D, et al (2012). A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens. J Clin Microbiol, 50, 3983-9.   DOI
33 Fiedorek SC, Malaty HM, Evans DL, et al (1991). Factors influencing the epidemiology of Helicobacter pylori infection in children. Pediatrics, 88, 578-82.
34 Franco AT, Israel DA, Washington MK, et al (2005). Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci U S A, 102, 10646-51.   DOI
35 Haile RW, John EM, Levine AJ, et al (2012). A review of cancer in U.S. Hispanic populations. Cancer Prev Res (Phila), 5, 150-63.   DOI
36 Gancz H, Jones KR, Merrell DS (2008). Sodium chloride affects Helicobacter pylori growth and gene expression. J Bacteriol, 190, 4100-5.   DOI
37 Gonzalez CA, Figueiredo C, Lic CB, et al (2011). Helicobacter pylori cagA and vacA genotypes as predictors of progression of gastric preneoplastic lesions: a long-term follow-up in a high-risk area in Spain. Am J Gastroenterol, 106, 867-74.   DOI
38 Gonzalez CA, Lujan-Barroso L, Bueno-de-Mesquita HB, et al (2012). Fruit and vegetable intake and the risk of gastric adenocarcinoma: a reanalysis of the European prospective investigation into cancer and nutrition (EPIC-EURGAST) study after a longer follow-up. Int J Cancer, 131, 2910-9.   DOI
39 Harrison LE, Zhang ZF, Karpeh MS, et al (1997). The role of dietary factors in the intestinal and diffuse histologic subtypes of gastric adenocarcinoma: a case-control study in the U.S. Cancer, 80, 1021-8.   DOI
40 Hennig EE, Mernaugh R, Edl J, et al (2004). Heterogeneity among Helicobacter pylori strains in expression of the outer membrane protein BabA. Infect Immun, 72, 3429-35.   DOI
41 Higashi H, Tsutsumi R, Muto S, et al (2002). SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori cagA protein. Science, 295, 683-6.   DOI
42 Honarmand-Jahromy S, Siavoshi F, Malekzadeh R, et al (2015). Reciprocal impact of host factors and Helicobacter pylori genotypes on gastric diseases. World J Gastroenterol, 21, 9317-27.   DOI
43 Ioannou GN, Rockey DC, Bryson CL, et al (2002). Iron deficiency and gastrointestinal malignancy: a population-based cohort study. Am J Med, 113, 276-80.   DOI
44 Kim HJ, Lim SY, Lee JS, et al (2010). Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies. Cancer Sci, 101, 508-16.   DOI
45 Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.   DOI
46 Jenab M, Riboli E, Ferrari P, et al (2006). Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Carcinogenesis, 27, 2250-7.   DOI
47 Joossens JV, Hill MJ, Elliott P, et al (1996). Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol, 25, 494-504.   DOI
48 Knekt P, Reunanen A, Takkunen H, et al (1994). Body iron stores and risk of cancer. Int J Cancer, 56, 379-82.   DOI
49 Ladeiras-Lopes R, Pereira AK, Nogueira A, et al (2008). Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control, 19, 689-701.   DOI
50 Loh JT, Friedman DB, Piazuelo MB, et al (2012). Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of cagA expression. Infect Immun, 80, 3094-106.   DOI
51 Matsuhisa TM, Yamada NY, Kato SK, et al (2003). Helicobacter pylori infection, mucosal atrophy and intestinal metaplasia in Asian populations: a comparative study in age-, gender- and endoscopic diagnosis-matched subjects. Helicobacter, 8, 29-35.   DOI
52 Megraud F (2001). Impact of Helicobacter pylori virulence on the outcome of gastroduodenal diseases: lessons from the microbiologist. Dig Dis, 19, 99-103.   DOI
53 Ogiwara H, Sugimoto M, Ohno T, et al (2009). Role of deletion located between the intermediate and middle regions of the Helicobacter pylori vacA gene in cases of gastroduodenal diseases. J Clin Microbiol, 47, 3493-500.   DOI
54 Moy KA, Fan Y, Wang R, et al (2010). Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev, 19, 2287-97.   DOI
55 Murata-Kamiya N, Kurashima Y, Teishikata Y, et al (2007). Helicobacter pylori cagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene, 26, 4617-26.   DOI
56 Nakaji S, Fukuda S, Sakamoto J, et al (2001). Relationship between mineral and trace element concentrations in drinking water and gastric cancer mortality in Japan. Nutr Cancer, 40, 99-102.   DOI
57 Pourfarzi F, Whelan A, Kaldor J, et al (2009). The role of diet and other environmental factors in the causation of gastric cancer in Iran--a population based study. Int J Cancer, 125, 1953-60.   DOI
58 Pra D, Rech Franke SI, Pegas Henriques JA, et al (2009). A possible link between iron deficiency and gastrointestinal carcinogenesis. Nutr Cancer, 61, 415-26.   DOI
59 Ren JS, Kamangar F, Forman D, et al (2012). Pickled food and risk of gastric cancer--a systematic review and meta-analysis of English and Chinese literature. Cancer Epidemiol Biomarkers Prev, 21, 905-15.   DOI
60 Rhead JL, Letley DP, Mohammadi M, et al (2007). A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterol, 133, 926-36.   DOI
61 Sonnenberg A (2010). Differences in the birth-cohort patterns of gastric cancer and peptic ulcer. Gut, 59, 736-43.   DOI
62 Shaffer CL, Gaddy JA, Loh JT, et al (2011). Helicobacter pylori exploits a unique repertoire of type IV secretion system components for pilus assembly at the bacteria-host cell interface. PLoS Pathog, 7, 1002237.   DOI
63 Shikata K, Doi Y, Yonemoto K, et al (2008). Population-based prospective study of the combined influence of cigarette smoking and Helicobacter pylori infection on gastric cancer incidence: the Hisayama Study. Am J Epidemiol, 168, 1409-15.   DOI
64 Soerjomataram I, Lortet-Tieulent J, Parkin DM, et al (2012). Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions. Lancet, 380, 1840-50.   DOI
65 Suzuki R, Shiota S, Yamaoka Y (2012). Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori. Infect Genet Evol, 12, 203-13.   DOI
66 Torres VJ, VanCompernolle SE, Sundrud MS, et al (2007). Helicobacter pylori vacuolating cytotoxin inhibits activation-induced proliferation of human T and B lymphocyte subsets. J Immunol, 179, 5433-40.   DOI
67 Tramacere I, Negri E, Pelucchi C, et al (2012). A meta-analysis on alcohol drinking and gastric cancer risk. Ann Oncol, 23, 28-36.   DOI
68 Tsugane S, Sasazuki S (2007). Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer, 10, 75-83.   DOI
69 Tyas SL, Pederson LL (1998). Psychosocial factors related to adolescent smoking: a critical review of the literature. Tob Control, 7, 409-20.   DOI