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http://dx.doi.org/10.7314/APJCP.2015.16.17.7755

Survey of Her2-neu Expression and its Correlation with Histology of Gastric Carcinoma and Gastroesophageal Junction Adenocarcinoma  

Madani, Seyed-Hamid (Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences)
Rahmati, Ali (Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences)
Sadeghi, Edris (Cancer Research Center, Kermanshah University of Medical Sciences)
Khazaei, Sedighe (Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences)
Sadeghi, Masoud (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Payandeh, Mehrdad (Medical Biology Research Center, Kermanshah University of Medical Sciences)
Amirifard, Nasrin (Cancer Research Center, Kermanshah University of Medical Sciences)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.17, 2015 , pp. 7755-7758 More about this Journal
Abstract
Background: There is increasing evidence that HER2-neu is an important biomarker in gastric carcinomas (GC) and gastroesophageal junction (GEJ) adenocarcinomas. The aim of this study was to evaluate HER2-neu expression and also some clinicopathological features of these neoplasms. Materials and Methods: We selected 211 paraffin-embedded blocks, 193 GC and 18 GEJ. Then 4 micron sections were prepared for staining with hematoxylin and eosin and also for IHC (Her2-neu). The Chi-square test was used for significance between expression of HER2-neu and clinicopathological parameters. Results: In patients with advanced cancer of GC and GEJ, HER2-neu overexpression was more associated with the intestinal cancer subtype. Conclusions: This could be a guide to new complementary therapy for affected patients.
Keywords
Gastric cancer; gastroesophageal cancer; Her2-neu; IHC;
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