Browse > Article
http://dx.doi.org/10.7314/APJCP.2014.15.6.2923

Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey  

Can, Alper (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University)
Dogan, Erkan (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University)
Bayoglu, Ibrahim Vedat (Department of Medical Oncology, Faculty of Medicine, Katip Celebi University)
Tatli, Ali Murat (Department of Medical Oncology, Regional Training and Research Hospital)
Besiroglu, Mehmet (Department of Medical Oncology, Faculty of Medicine Marmara University)
Kocer, Murat (Department of Medical Oncology, Faculty of Medicine Sulayman Demirel University)
Dulger, Ahmet Cumhur (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University)
Uyeturk, Ummugul (Department of Medical Oncology, Faculty of Medicine, Izzet Baysal University)
Kivrak, Derya (Department of Medical Oncology, Faculty of Medicine, Akdeniz University)
Orakci, Zuat (Department of Medical Oncology, Faculty of Medicine Dicle University)
Bal, Oznur (Department of Medical Oncology, Regional Training and Research Hospital)
Kacan, Turgut (Department of Medical Oncology, Faculty of Medicine Cumhuriyet University)
Olmez, Sehmus (Department of Medical Oncology, Faculty of Medicine, Van Yuzuncu Yil University)
Turan, Nedim (Department of Medical Oncology, Regional Training and Research Hospital)
Ozbay, Mehmet Fatih (Department of Medical Oncology, Regional Training and Research Hospital)
Alacacioglu, Ahmet (Department of Medical Oncology, Faculty of Medicine, Katip Celebi University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.6, 2014 , pp. 2923-2927 More about this Journal
Abstract
Background: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male:female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.
Keywords
Hepatocellular carcinoma; etiologic factors; alpha-fetoprotein; Turkey;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Turkey Liver Research Association National Hepatitis Often Study (TURKHEP 2010).
2 Zidan A, Scheuerlein H, Schule S, et al (2012). Epidemiological pattern of hepatitis B and hepatitis C as etiological agents for hepatocellular carcinoma in Iran and wordwide. Hepat Mon, 12, 14-22.
3 Wang BE, Ma WM, Sulaiman A, et al (2002). Demographic, clinical, and virological characteristics of hepatocellular carcinoma in Asia: survey of 414 patients from four countries. J Med Virol, 67, 394-400.   DOI   ScienceOn
4 Stuart KE, Anand AJ, Jenkins RL (1996). Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival. Cancer, 77, 2217-22.   DOI
5 Su CH, Lin Y, Cai L (2013). enetic factors, viral infection, other factors and liver cancer: an update on current progress. Asian Pac J Cancer Prev, 14, 49053-60.
6 Yaprak O, Akyildiz M, Dayangac M, et al (2012). AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int, 11, 256-61.   DOI   ScienceOn
7 Uzunalimoglu O, Yurdaydin C, Cetinkaya H, et al (2001). Risk factors for hepatocellular carcinoma in Turkey. Dig Dis Sci, 46, 1022-8.   DOI   ScienceOn
8 Xu J, Liu C, Zhou L, et al (2012). Distinctions between clinicopathological factors and prognosis of alphafetoprotein negative and positive hepatocellular carcinoma patients. Asian Pac J Cancer Prev, 13, 559-62.   DOI   ScienceOn
9 Yalcin K, Yakut M, Degertekin H, et al (2013). Clinical and epidemiological characteristics of hepatocellular carsinoma cases in East and Southeastern Region of Turkey. Clin J Med, 33, 806-13.
10 Yeo Y, Gwack J, Kang S, et al (2013). Viral hepatitis and liver cancer in Korea: an epidemiological perspective. Asian Pac J Cancer Prev, 14, 6227-31.   DOI   ScienceOn
11 Zhang BH, Yang BH, Tang ZY (2004). Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol, 130, 417-22.
12 Monto A, Wright TL (2001). The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol, 28, 441-9.   DOI   ScienceOn
13 Lim HY, Sohn I, Deng S, et al (2013). Prediction of disease-free survival in hepatocellular carcinoma by gene expression profiling. Ann Surg Oncol, 20, 3747-53.   DOI   ScienceOn
14 Markovic S, Gadzijev E, Stabuc B, et al (1998). Treatment options in Western hepatocellular carcinoma: a prospective study of 224 patients. J Hepatol, 29, 650-9.   DOI   ScienceOn
15 Marrero CR, Marrero JA (2007). Viral hepatitis and hepatocellular carcinoma. Arch Med Res, 38, 612-20.   DOI   ScienceOn
16 Norsa'adah B, Nurhazalini-Zayani CG (2013). Epidemiology and survival of hepatocellular carcinoma in north-east peninsular Malaysia. Asian Pac J Cancer Prev, 14, 6955-9.   DOI   ScienceOn
17 Schoniger-Hekele M, Muller C, Kutilek M, et al (2001). Hepatocellular carcinoma in Central Europe: prognostic features and survival. Gut, 48, 103-9.   DOI
18 Ozer B, Serin E, Yilmaz U, et el (2003). Clinicopathologic features and risk factors for hepatocellular carcinoma: results from a single center in southern Turkey. Turk J Gastroenterol, 14, 85-90.
19 Purtilo DT, Kersey JH, Hallgren HM, et al (1973). Alphafetoprotein: diagnostic and prognostic use in patients with hepatomas. Am J Clin Pathol, 59, 295-9.
20 Sakar B, Ustuner Z, Karagol H, et al (2004). Prognostic features and survival of inoperable hepatocellular carcinoma in Turkish patients with cirrhosis. Am J Clin Oncol, 27, 489-93.   DOI   ScienceOn
21 Stroffolini T, Andreone P, Andriulli A, et al (1998). Characteristics of hepatocellular carcinoma in Italy. J Hepatol, 29, 944-52.   DOI   ScienceOn
22 Fong Y, Sun RL, Jarnagin W, et al (1999). An analysis of 412 cases of hepatocellular carcinoma at a Western center. Ann Surg, 229, 790-800.   DOI   ScienceOn
23 Bruix J, Sherman M (2005). Menagement of hepatocellular carcinoma. An update. AASLD Practice Guidelines.
24 Chang HC, Lin YM, Yen AMF, et al (2013). Predictors of longterm survival in hepatocellular carcinomas: a longitudinal follow-up of 108 patients with small tumors. Anticancer Res, 33, 5171-8
25 Dogan E, Yalcin S, Koca D, et al (2012). Clinicopathological characteristics of hepatocellular carcinoma in Turkey. Asian Pac J Cancer Prev, 13, 2985-90.   DOI   ScienceOn
26 Geramizadeh B, Asadi N, Tabei SZ (2012). Cytologic comparison between malignant and regenerative nodules in the background of cirrhosis. Hepat Mon, 12, 448-52   DOI   ScienceOn
27 Lee CH, Hsieh SY, Lin JL et al (2013). Hepatocellular carcinoma in patients with chronic kidney disease. World J Gastroenterol ,19, 2466-72.   DOI   ScienceOn
28 Hassan MM, Hwang LY, Hatten CJ, et al (2002) Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology, 36, 1206-13.   DOI   ScienceOn
29 Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50.   DOI   ScienceOn
30 Lee FI (1966). Cirrhosis and hepatoma in alcoholics. Gut, 7, 77-85.   DOI
31 Lehman EM, Wilson ML (2009). Epidemiology of hepatitis viruses among hepatocellular car cinoma cases and healthy people in Egypt: a systematic review and meta-analysis. Int J Cancer, 124, 690-7.   DOI   ScienceOn
32 Bosch FX, Ribes J, Borras J (1999). Epidemiology of primary liver cancer. Semin Liver Dis, 19, 271-85.   DOI   ScienceOn
33 Alacacioglu A, Somali I, Simsek I, et al (2008). Epidemiology and survival of hepatocellular carcinoma in Turkey: outcome of multicenter study. Jpn J Clin Oncol, 38, 683-8.   DOI   ScienceOn
34 Borzio M, Colloredo G, Pioltelli P, et al (2007). Epidemiology and outcome of hepatocellular carcinoma in Lombardy. Dig Liver Dis, 39, 1011-7.   DOI   ScienceOn
35 Beasley RP, Hwang LY, Lin CC, et al (1981). Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet, 21, 1129-33.