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http://dx.doi.org/10.7314/APJCP.2014.15.17.7251

Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis  

Lin, Zhuo (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University)
Chen, Li (Institute of Genomic Medicine, Wenzhou Medical University)
Song, Mei (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University)
Shi, Ke-Qing (Department of Infection and Liver Diseases, Institution of Hepatology, the First Affiliated Hospital of Wenzhou Medical University)
Tang, Kai-Fu (Institute of Genomic Medicine, Wenzhou Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.17, 2014 , pp. 7251-7255 More about this Journal
Abstract
MicroRNAs (miRNAs) act as tumor suppressors or promoters in neoplasia by regulating relative geneexpression. The association between a single nucleotide polymorphism (SNP) rs4938723 in miR-34b/c and susceptibility to cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed, Web of Science and Embase to identify all relevant studies in this meta-analysis with 6,036 cases and 6,204 controls. We found that the miR-34b/c rs4938723 polymorphism was significantly associated with increased risk of cancers in the heterozygous model (TC versus TT, OR=1.09, 95% CI=1.01-1.18, P=0.02). Subgroup analysis also revealed increased risk for Asian ethnicity in the heterozygous model (TC versus TT, OR=1.12, 95% CI=1.02-1.22, P=0.02), but decreased risk of colorectal cancer in homozygote model (CC versus TT, OR=0.66, 95% CI=0.47-0.92, P=0.02) and in the recessive model (CC versus TC+TT, OR=0.67, 95% CI=0.48-0.93, P=0.02) by cancer type. The current meta-analysis indicated that the miR-34b/c rs4938723 polymorphism may decrease susceptibility to colorectal cancer. Well-designed studies with larger sample size are required to further validate the results.
Keywords
miR; 34b/c; rs4938723; polymorphism; cancer; meta-analysis;
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