Targeted Silencing of Inhibitors of Apoptosis Proteins with siRNAs: A Potential Anti-cancer Strategy for Hepatocellular Carcinoma |
Li, Gang
(Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University)
Chang, Hong (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) Zhai, Yun-Peng (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) Xu, Wei (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) |
1 | Wang H, Tan SS, Wang XY, et al (2007). Silencing livin gene by siRNA leads to apoptosis induction, cell cycle arrest, proliferation inhibition in malignant melanoma LiBr cells. Acta Pharmacol Sin, 28, 1968-74. DOI ScienceOn |
2 | Wei Y, Fan T, Yu M (2008). Inhibitor of apoptosis proteins and apoptosis. Acta Biochim Biophys Sin (Shanghai), 40,278-88. DOI ScienceOn |
3 | Wang S, Bai L, Lu J, et al (2012). Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. J Mammary Gland Biol Neoplasia, 17, 217-28. DOI |
4 | Wang TS, Ding QQ, Guo RH, et al (2010). Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin gene. Biomed Pharmacother, 64, 333-8. DOI ScienceOn |
5 | Wei W, Wanjun L, Hui S, et al (2013). miR-203 inhibits proliferation of HCC cells by targeting survivin. Cell Biochem Fund, 31, 82-5. DOI ScienceOn |
6 | Wong LL (2002). Current status of liver transplantation for hepatocellular cancer. Am J Surg, 183, 309-16. DOI ScienceOn |
7 | Wu G, Chai J, Suber TL, et al (2000). Structural basis of IAP recognition by Smac/DIABLO. Nature, 408, 1008-12. DOI ScienceOn |
8 | Wu L, Wang Y, Tian D (2007). Knockdown of survivin expression by siRNA induces apoptosis of hepatocellular carcinoma cells. J Huazhong Unix Sci Technolog Med Sci, 27, 403-6. DOI |
9 | Xiang Y, Yao H, Wang S, et al (2006). Prognostic value of Survivin and Livin in nasopharyngeal carcinoma. Laryngoscope, 116, 126-30. DOI ScienceOn |
10 | Yahya RS, Fouda MI, El-Baz HA, Mosa TE, Elmaksoud MD (2012). Serum Survivin and TP53 Gene Expression in Children with Acute Lymphoblastic Leukemia. Iran J Public Health, 41, 37-44. |
11 | Yang D, Song X, Zhang J, et al (2010). Suppression of livin gene expression by siRNA leads to growth inhibition and apoptosis induction in human bladder cancer T24 cells. Biosci Biotechnol Biochem, 74, 1039-44. DOI ScienceOn |
12 | Yuan D, Liu L, Xu H, Gu D (2009). The effects on cell growth and chemosensitivity by livin RNAi in non-small cell lung cancer. Mol Cell Biochem, 320, 133-40. DOI |
13 | Yang H, Fu JH, Hu Y, et al (2008). Influence of SiRNA targeting survivin on chemosensitivity of H460/cDDP lung cancer cells. J Int Med Res, 36, 734-47. DOI |
14 | Yang M, Liu Y, Lu S, et al (2013). Analysis of the expression levels of survivin and VEGF in patients with acute lymphoblastic leukemia. Exp Ther Med, 5, 305-7. DOI |
15 | Yuan B, Ran B, Wang S, et al (2012). siRNA directed against Livin inhibits tumor growth and induces apoptosis in human glioma cells. J Neurooncol, 107, 81-7. DOI ScienceOn |
16 | Zaffaroni N, Pennati M, Daidone MG (2005). Survivin as a target for new anticancer interventions. J Cell Mol Med, 9, 360-72. DOI ScienceOn |
17 | Zender L, Spector MS, Xue W, et al (2006). Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125, 1253-67. DOI ScienceOn |
18 | Zhang M, Yang J, Li F (2006). Transcriptional and post- transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment. J Exp Clin Cancer Res, 25, 391-402. |
19 | Zhang R, Ma L, Zheng M, et al (2010). Survivin knockdown by short hairpin RNA abrogates the growth of human hepatocellular carcinoma xenografts in nude mice. Cancer Gene Ther, 17, 275-88. DOI ScienceOn |
20 | Zhang S, Ding F, Luo A, et al (2007). XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics. Cancer Biol Ther, 6, 973-80. |
21 | Zhu H, Chen XP, Zhang WG, Luo SF, Zhang BX (2005). Expression and significance of new inhibitor of apoptosis protein survivin in hepatocellular carcinoma. World J Gastroenterol, 11, 3855-9. DOI |
22 | Akyurek N, Ren Y, Rassidakis GZ, Schlette EJ, Medeiros LJ (2006). Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas. Cancer, 107, 1844-51. DOI ScienceOn |
23 | Altieri DC (2003). Survivin in apoptosis control and cell cycle regulation in cancer. Prog Cell Cycle Res, 5, 447-52. |
24 | Ashhab Y, AlianA, PolliackA, PanetA, Ben Yehuda D (2001). Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett, 495, 56-60. DOI ScienceOn |
25 | Augello C, Caruso L, Maggioni M, et al (2009). Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer, 9, 125. DOI ScienceOn |
26 | Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409, 363-6. DOI ScienceOn |
27 | Bhattacharyya M, Lemoine NR (2006). Gene therapy developments for pancreatic cancer. Best Pract Res Clin Gastroenterol, 20, 285-98. |
28 | Bilim V, Yuuki K, Itoi T, et al (2008). Double inhibition of XIAP and Bcl-2 axis is beneficial for retrieving sensitivity of renal cell cancer to apoptosis. Br J Cancer, 98, 941-9. DOI ScienceOn |
29 | Bosch FX, Ribes J, Diaz M, Cleries R (2004). Primary liver cancer: worldwide incidence and trends. Gastroenterology, 127, S5-16. DOI ScienceOn |
30 | Buneker CK, Yu R, Deedigan L, Mohr A, Zwacka RM (2012). IFN-gamma combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells. Cancer Lett, 316, 168-77. DOI ScienceOn |
31 | Caldas H, Holloway MP, Hall BM, Qualman SJ, Altura RA (2006). Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo. J Med Genet, 43, 119-28. |
32 | Capalbo G, Rodel C, Stauber RH, et al (2007). The role of survivin for radiation therapy. Prognostic and predictive factor and therapeutic target. Strahlenther Onkol, 183, 593-9. DOI |
33 | Chai J, Shiozaki E, Srinivasula SM, et al (2001). Structural basis of caspase-7 inhibition by XIAP Cell, 104, 769-80. DOI ScienceOn |
34 | Chang H (2007). RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research. Cancer Gene Ther, 14, 677-85. DOI ScienceOn |
35 | Che Y, Ye F, Xu R, et al (2012). Co-expression of XIAP and cyclin Dl complex correlates with a poor prognosis in patients with hepatocellular carcinoma. Am J Pathol, 180, 1798-807. DOI ScienceOn |
36 | Chen J,XiaoXQ, DengCM, SuXS, Li GY (2006). Downregulation of xIAP expression by small interfering RNA inhibits cellular viability and increases chemosensitivity to methotrexate in human hepatoma cell line HepG2. J Chemother, 18,525-31. DOI ScienceOn |
37 | Chen Z, Naito M, Hori S, et al (1999). A human IAP-family gene, apollon, expressed in human brain cancer cells. Biochem Biophys Res Commun, 264, 847-54. DOI ScienceOn |
38 | Cotman CW (1998). Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging, 19, S29-32. DOI ScienceOn |
39 | Chu L, Gu J, Sun L, et al (2008). Oncolytic adenovirus-mediated shRNA against Apollon inhibits tumor cell growth and enhances antitumor effect of 5-fluorouracil. Gene Ther, 15, 484-94. DOI ScienceOn |
40 | Cillessen SA, Reed JC, Welsh K, et al (2008). Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. Blood, 111, 369-75. DOI ScienceOn |
41 | Couzin J (2002). Breakthrough of the year. Small RNAs make big splash. Science, 298, 2296-7. DOI ScienceOn |
42 | Crnkovic-Mertens I, Muley T, Meister M, et al (2006). The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells. Lung Cancer, 54, 135-42. DOI ScienceOn |
43 | Crook NE, Clem RJ, Miller LK (1993). An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol, 67, 2168-74 |
44 | Cryns V, Yuan J (1998). Proteases to die for. Genes Dev, 12, 1551-70. DOI ScienceOn |
45 | DasguptaA, Alvarado CS, Xu Z, Findley HW (2010). Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma. Biochem Biophys Res Commun, 400, 53-9. DOI ScienceOn |
46 | Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE (2004). Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9. J Biol Chem, 279, 40622-8. DOI ScienceOn |
47 | Endo T, Abe S, Seidlar HB, et al (2004). Expression of IAP family proteins in colon cancers from patients with different age groups. Cancer Immunol Immunother, 53, 770-6. |
48 | Dickins RA, McJunkin K, Hernando E, et al (2007). Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet, 39, 914-21. DOI ScienceOn |
49 | Eckelman BP, Salvesen GS, Scott FL (2006). Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep, 7, 988-94. DOI ScienceOn |
50 | El-Mesallamy HO, Hegab HM, Kamal AM (2011). Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome. Leuk Res, 35, 1616-22. DOI ScienceOn |
51 | Esposito I, Kleeff J, Abiatari I, et al (2007). Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer. J Clin Pathol, 60, 885-95. |
52 | Fabregat I (2009). Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol, 15, 513-20. DOI |
53 | Gazzaniga P, Gradilone A, Giuliani L, et al (2003). Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer. Ann Oncol, 14, 85-90. DOI ScienceOn |
54 | Ge QX, Li YY, Nie YQ, Zuo WG, Du YL (2013). Expression of survivin and its four splice variants in colorectal cancer and its clinical significances. Med Oncol, 30, 535. DOI ScienceOn |
55 | Giagkousiklidis S, Vellanki SH, Debatin KM, Fulda S (2007). Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAPinhibition. Oncogene, 26,7006-16. DOI ScienceOn |
56 | Hauser HP, Bardroff M, Pyrowolakis G, Jentsch S (1998). A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors. J Cell Biol, 141, 1415-22. DOI |
57 | Giering JC, Grimm D, Storm TA, Kay MA (2008). Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Mol Ther, 16, 1630-6. DOI ScienceOn |
58 | Hartmann A, Hunot S, Michel PR et al (2000). Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl AcadSci USA, 97, 2875-80. DOI ScienceOn |
59 | Hatano M, Mizuno M, Yoshida J (2004). Enhancement of C2-ceramide antitumor activity by small interfering RNA on X chromosome-linked inhibitor of apoptosis protein in resistant human glioma cells. J Neurosurg, 101, 119-27. DOI ScienceOn |
60 | Hiscutt EL, Hill DS, Martin S, et al (2010). Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy. J Invest Dermatol, 130, 2250-8. DOI ScienceOn |
61 | Huang Y, Park YC, Rich RL, et al (2001). Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell, 104, 781-90. |
62 | Hung CS, Lin SF, Liu HH, et al (2012). Survivin-mediated therapeutic efficacy of gemcitabine through glucose-regulated protein 78 in hepatocellular carcinoma. Ann Surg Oncol, 19, 2744-52. DOI ScienceOn |
63 | Izquierdo M (2005). Short interfering RNAs as a tool for cancer gene therapy. Cancer Gene Ther, 12, 217-27. DOI ScienceOn |
64 | Karagiannis TC, El-Osta A (2005). RNA interference and potential therapeutic applications of short interfering RNAs. Cancer Gene Ther, 12, 787-95. DOI ScienceOn |
65 | Kasof GM, Gomes BC (2001). Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem, 276, 3238-46. DOI ScienceOn |
66 | LaCasse EC, Mahoney DJ, Cheung HH, et al (2008). IAP-targeted therapies for cancer. Oncogene, 27, 6252-75. DOI ScienceOn |
67 | Kempkensteffen C, Fritzsche FR, Johannsen M, et al (2009). Down-regulation of the pro-apoptotic XIAP associated factor-1 (XAF1) during progression of clear-cell renal cancer. BMC Cancer, 9, 276. DOI ScienceOn |
68 | Kesari A, Misra UK, Kalita J, et al (2005). Study of survival of motor neuron (SMN) and neuronal apoptosis inhibitory protein (NAIP) gene deletions in SMA patients. J Neurol, 252, 667-71. DOI |
69 | Kroemer G, Reed JC (2000). Mitochondrial control of cell death. Nat Med, 6, 513-9. DOI ScienceOn |
70 | Lazar I, Perlman R, Lotem M, et al (2012). The clinical effect of the inhibitor of apopotosis protein livin in melanoma. Oncology, 82, 197-204. DOI ScienceOn |
71 | Li F (2003). Survivin study: what is the next wave? J Cell Physiol, 197, 8-29. DOI ScienceOn |
72 | Li F (2005). Role of survivin and its splice variants in tumorigenesis. Br J Cancer, 92, 212-6. DOI |
73 | Li SX, Chai L, Cai ZG, et al (2012). Expression of survivin and caspase 3 in oral squamous cell carcinoma and peritumoral tissue. Asian Pac J Cancer Prev, 13, 5027-31. DOI ScienceOn |
74 | Lima RT, Martins LM, Guimaraes JE, Sambade C, Vasconcelos MH (2004). Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. Cancer Gene Ther, 11, 309-16. DOI ScienceOn |
75 | Liu B, Han M, Wen JK, Wang L (2007). Livin/ML-IAP as a new target for cancer treatment. Cancer Lett, 250, 168-76. DOI ScienceOn |
76 | Liu WS, Yan HJ, Qin RY, et al (2009b). siRNA directed against survivin enhances pancreatic cancer cell gemcitabine chemosensitivity. Dig Dis Sci, 54, 89-96. DOI |
77 | Liu H, Wang S, Sun H, et al (2010). Inhibition of tumorigenesis and invasion of hepatocellular carcinoma by siRNA-mediated silencing of the livin gene. Mol Med Rep, 3, 903-7. |
78 | Liu HB, Kong CZ, Zeng Y, et al (2009a). Livin may serve as a marker for prognosis of bladder cancer relapse and a target of bladder cancer treatment. Urol Oncol, 27, 277-83. DOI ScienceOn |
79 | Liu W, Zhu F, Jiang Y, et al (2013). siRNA targeting survivin inhibits the growth and enhances the ch,mosensitivity of hepatocellular carcinoma cells. Oncol Rep, 29, 1183-8. DOI |
80 | Liu Z, Sun C, Olejniczak ET, et al (2000). Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature, 408, 1004-8. DOI ScienceOn |
81 | Llovet JM, Bruix J (2008). Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol, 48, S20-37. |
82 | Lopergolo A, Pennati M, Gandellini P, et al (2009). Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation. Br J Cancer, 100, 739-46. |
83 | Ma JJ, Chen BL, Xin XY (2009). XIAP gene downregulation by small interfering RNA inhibits proliferation, induces apoptosis, reverses the cisplatin resistance of ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol, 146, 222-6. DOI ScienceOn |
84 | Maier JK, Lahoua Z, Gendron NH, et al (2002). The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J Neurosci, 22, 2035-43. |
85 | Notarbartolo M, Cervello M, Giannitrapani L, et al (2004). Expression of IAPs and alternative splice variants in hepatocellular carcinoma tissues and cells. Ann N Y Acad Sci, 1028, 289-93. DOI ScienceOn |
86 | Mansouri A, Zhang Q, Ridgway LD, Tian L, Claret FX (2003). Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation. Oncol Res, 13, 399-404. DOI |
87 | Notarbartolo M, Cervello M, Dusonchet L, D'Alessandro N (2002). NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells. Leuk Res, 26, 857-62. DOI ScienceOn |
88 | Oh BY, Lee RA, Kim KH (2011). siRNA targeting Livin decreases tumor in a xenograft model for colon cancer. World J Gastroenterol, 17, 2563-71. DOI ScienceOn |
89 | Qiu XB, Markant SL, Yuan J, Goldberg AL (2004). Nrdpl-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J, 23,800-10. DOI ScienceOn |
90 | Ramp U, Krieg T, Caliskan E, et al (2004). XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. Hum Pathol, 35, 1022-8. DOI ScienceOn |
91 | Ren J, Shi M, Liu R, et al (2005). The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc Natl Acad Sci USA, 102, 565-70. DOI ScienceOn |
92 | Richter BW, Mir SS, Eiben LJ, et al (2001). Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol, 21, 4292-301. DOI ScienceOn |
93 | Salvesen GS, Duckett CS (2002). IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol, 3, 401-10. DOI ScienceOn |
94 | Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1995). The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell, 83, 1243-52. DOI ScienceOn |
95 | Ruckert F, Samm N, Lehner AK, et al (2010). Simultaneous gene silencing of Bcl-2, XIAP and Survivin re-sensitizes pancreatic cancer cells towards apoptosis. BMC Cancer, 10, 379. DOI ScienceOn |
96 | Ryan BM, Konecny GE, Kahlert S, et al (2006). Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-l. Ann Oncol, 17, 597-604. DOI ScienceOn |
97 | Shankar P, Manjunath N, Lieberman J (2005). The prospect of silencing disease using RNA interference. JAMA, 293, 1367-73. DOI ScienceOn |
98 | Shi Y (2002). Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell, 9, 459-70. DOI ScienceOn |
99 | Shi YH, Ding WX, Zhou J, et al (2008). Expression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrence. Hepatology, 48, 497-507. DOI ScienceOn |
100 | Shiozaki EN, Chai J, Rigotti DJ, et al (2003). Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell, 11, 519-27. DOI ScienceOn |
101 | Shiraki K, Sugimoto K, Yamanaka Y, et al (2003). Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma. Int J Mol Med, 12, 705-8. |
102 | Shrikhande SV, Kleeff J, Kayed H, et al (2006). Silencing of X-linked inhibitor of apoptosis (XIAP) decreases gemcitabine resistance of pancreatic cancer cells. Anticancer Res, 26, 3265-73. |
103 | Srinivasula SM, Hegde R, Saleh A, et al (2001). A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature, 410, 112-6. DOI ScienceOn |
104 | Smith CA, Farrah T, Goodwin RG (1994). The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, death. Cell, 76, 959-62. DOI ScienceOn |
105 | Song X, Wang JB, Yin DL, et al (2009). Down-regulation of lung resistance related protein by RNA interference targeting survivin induces the reversal of chemoresistances in hepatocellular carcinoma. Chin Med J (Engl), 122, 2636-42. |
106 | Sprenger T, Rodel F, Beissbarth T, et al (2011). Failure of downregulation of survivin following neoadjuvant radiochemotherapy in rectal cancer is associated with distant metastases and shortened survival. Clin Cancer Res, 17, 1623-31. DOI |
107 | Sung KW, Choi J, Hwang YK, et al (2007). Overexpression of Apollon, an antiapoptotic protein, is associated with poor prognosis in childhood de novo acute myeloid leukemia. Clin Cancer Res, 13, 5109-14. DOI ScienceOn |
108 | Takashima H, Nakajima T, Moriguchi M, et al (2005). In vivo expression patterns of survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma. Liver Int, 25, 77-84. DOI ScienceOn |
109 | Takeuchi H, Kim J, Fujimoto A, et al (2005a). X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. Clin Cancer Res, 11, 7621-8. |
110 | Takeuchi H, Morton DL, Elashoff D, Hoon DS (2005b). Survivin expression by metastatic melanoma predicts poor disease outcome in patients receiving adjuvant polyvalent vaccine. Int J Cancer, 117, 1032-8. DOI ScienceOn |
111 | Tanabe H, Yagihashi A, Tsuji N, et al (2004). Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer. Lung Cancer, 46, 299-304 DOI ScienceOn |
112 | Varfolomeev E, Goncharov T, Fedorova AV, et al (2008). c-IAPl and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem, 283, 24295-9. DOI ScienceOn |
113 | Tartaglia LA, Goeddel DV (1992a). Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor. J Biol Chem, 267, 4304-7. |
114 | Tartaglia LA, Goeddel DV (1992b). Two TNF receptors. Immunol Today, 13, 151-3. |
115 | Thornberry NA, Lazebnik Y (1998). Caspases: enemies within. Science, 281, 1312-6. DOI ScienceOn |
116 | Vucic D, Deshayes K, Ackerly H, et al (2002). SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). J Biol Chem, 277, 12275-9. DOI ScienceOn |
117 | Vucic D, Fairbrother WJ (2007). The inhibitor of apoptosis proteins as therapeutic targets in cancer. Clin Cancer Res, 13, 5995-6000. DOI ScienceOn |
118 | Vucic D, Franklin MC, Wallweber HJ, et al (2005). Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP Biochem J, 385, 11-20. DOI ScienceOn |
119 | Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS, Jr. (1998). NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAPl and C-IAP2 to suppress caspase-8 activation. Science, 281, 1680-3. DOI ScienceOn |
120 | Chai J, Du C, Wu JW, et al (2000). Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature, 406, 855-62. DOI ScienceOn |
121 | Choi J, Hwang YK, Choi YJ, et al (2007). Neuronal apoptosis inhibitory protein is overexpressed in patients with unfavorable prognostic factors in breast cancer. J Korean Med Sci, 22, S17-23. DOI ScienceOn |
122 | Fuessel S, Herrmann J, Ning S, et al (2006). Chemosensitization of bladder cancer cells by survivin-directed antisense oligodeoxynucleotides and siRNA. Cancer Lett, 232, 243-54. DOI ScienceOn |
123 | Lin JH, Deng G, Huang Q, Morser J (2000). KIAP, a novel member of the inhibitor of apoptosis protein family. Biochem Biophys Res Commun, 279, 820-31. DOI ScienceOn |
124 | Merry DE, Korsmeyer SJ (1997). Bcl-2 gene family in the nervous system. Annu Rev Neurosci, 20, 245-67. DOI ScienceOn |
125 | Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM (2000). ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol, 10, 1359-66. DOI ScienceOn |