Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.7.4335

Betel Quid Chewing and Upper Aerodigestive Tract Cancers: A Prospective Cohort Study in Khon Kaen, Thailand  

Kampangsri, Wilas (Nongkungsri Public Health Office)
Vatanasapt, Patravoot (Department of Otorhinolaryngology, Faculty of Medicine, Khon Kaen University)
Kamsa-ard, Siriporn (Department of Biostatistics and Demography, Faculty of Public Health, Khon Kaen University)
Suwanrungruang, Krittika (Cancer Unit, Faculty of Medicine, Khon Kaen University)
Promthet, Supannee (Department of Epidemiology, Faculty of Public Health, Khon Kaen University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.7, 2013 , pp. 4335-4338 More about this Journal
Abstract
Background: This study aimed to determine the association between betel quid chewing and the occurrence of upper aerodigestive tract (UADT) cancers. Methods: A cohort of 17,388 subjects, recruited and interviewed over the 1990-2001 period, in Khon Kaen, Thailand, was followed up until 2011. The data were linked to the Khon Kaen Population-Based Cancer Registry. Results: The prevalence of betel quid chewing was 15.9%, with a female predominance (97.7%); the mean age of chewers was 57.7 years (SD 6.6). The overall incidence of UADT cancers from the cohort was 14.7 per 100,000 person-years, whereas the incidence among the chewers was 45.7. Betel nut chewing was the only major risk factor for UADT cancers in this population (HR=5.26, 95%CI=2.51-11.0), while weak associations were found for tobacco smoking and alcohol (HR=1.16, 95%CI=0.45-3.01 and 1.47, 95%CI=0.72-3.03 respectively). Conclusions: We found betel quid chewing to be a main risk factor for UADT cancers, resulting in a higher incidence in females. However, further study is required to explore the potential risk factors among non-chewers, non-smokers, and non-drinkers.
Keywords
Betel nut chewing; upper aerodigestive tract cancers; cohort study; Thailand;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Akhtar S, Sheikh A, Qureshi H (2012). Chewing areca nut, betel quid, oral snuff, cigarette smoking and the risk of oesophageal squamous-cell carcinoma in South Asians: a multicentre case-control Study. Eur J Cancer, 48, 655-61.   DOI   ScienceOn
2 Amarasinghe H, Usgodaarachchi U, Johnson N, et al (2010). Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control Study. Oral Oncol, 46, 297-301.   DOI   ScienceOn
3 Boonyaphiphat P, Thongsuksai P, Sriplung H, et al (2002). Life style habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. Cancer Letters, 186, 193-9.   DOI   ScienceOn
4 Ferlay J, Shin HR, Bray F, et al (2010). Globocan 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer, 2010. Available from: http:// globocan.iarc.fr.
5 Gupta PC, Warnakulasuriya S (2002). Global epidemiology of areca nut usage. Addict Biol, 7, 77-83.   DOI
6 Herrero R, Castellsague X, Pawlita M, et al (2003). Human papilloma virus and oral cancer: the international agency for research on cancer multicenter study. J Natl Cancer I, 95, 1772-83.   DOI   ScienceOn
7 IARC (2004). Working group on the evaluation of carcinogenic risks to humans. Betel-quid and areca-nut chewing and some areca-nut derived nitrosamines. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans/World Health Organization, International Agency for Research on Cancer, 85, 1-334.
8 Khuhaprema T, Attasara P, Sriplung H, et al (2012). Cancer in Thailand, Vol.VI, 2004-2006. Bangkok: Ministry of Public Health.
9 Kreimer A, Clifford G, Boyle P, et al (2005). Human papilloma virus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidem Biomar, 14, 467-75.   DOI   ScienceOn
10 Lee KW, Kuo WR, Tsai SM, et al (2005). Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer. Int J Cancer, 117, 831-6.   DOI   ScienceOn
11 Lin WJ, Jiang RS, Wu SH, et al (2011). Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study. J Oncol, 2011, 1-5.
12 Loyha K, Vatanasapt P, Promthet S, et al (2012). Risk factors for oral cancer in Northeast Thailand. Asian Pac J Cancer Prev, 13, 5087-90.   DOI   ScienceOn
13 Prateepko S (1998). A case-control study on risk factors for oral cancer in Southern Thailand. Master of Science Thesis in Epidemiology, Songkla, Thailand: Prince of Songkla University.
14 Qiu W, Chavarro J, Lazarus R, et al (2012). Power and sample size calculation for survival analysis of epidemiological studies. CRAN, 1-52.
15 Reichart PA, Supanchart C, Khongkhunthian P (2007). Traditional chewing and smoking habits from the point of view of Northern Thai betel quid vendors. Oral Health Prev Dent, 5, 245-9.
16 Simarak S, de Jong UW, Breslow N, et al (1977). Cancer of the oral cavity, pharynx/larynx and lung in North Thailand: case-control study and analysis of cigar smoke. Bri J Cancer, 36, 130-40.   DOI   ScienceOn
17 Sriamporn S, Parkin DM, Pisani P, et al (2005). A prospective study of diet, lifestyle, and genetic factors and the risk of cancer in Khon Kaen province, Northeast Thailand: Description of the cohort. Asian Pac J Cancer Prev, 6, 295-303.
18 Vatanasapt V, Martin N, Sriplung H, et al (1995). Cancer incidence in Thailand, 1988-1991. Cancer Epidemiol, Biomarkers and Prev, 4, 475-83.
19 Thomas SJ, Bain CJ, Battistutta D, et al (2007). Betel quid not containing tobacco and oral cancer: a report on a case-control study in Papua New Guinea and a meta-analysis of current evidence. Int J Cancer, 120 ,1318-23.   DOI   ScienceOn
20 Vatanasapt P, Suwanrungruang K, Kamsa-Ard S, et al (2011). Epidemiology of oral and pharyngeal cancers in Khon Kaen, Thailand: a high incidence in females. Asian Pac J Cancer Prev, 12, 2505-8.
21 Yen TT, Lin WD, Wang CP, et al (2008). The association of smoking, alcoholic consumption, betel quid chewing and oral cavity cancer: a cohort study. Eur Arch Oto-Rhino-L, 265, 1403-7.   DOI