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http://dx.doi.org/10.7314/APJCP.2012.13.4.1401

Polysaccharide Extracted from Rheum Tanguticum Prevents Irradiation-induced Immune Damage in Mice  

Liu, Lin-Na (Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University)
Guo, Zhi-Wei (Buerjin County People's Hospital)
Zhang, Yan (Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University)
Qin, Hua (Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University)
Han, Yan (Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.4, 2012 , pp. 1401-1405 More about this Journal
Abstract
Aim: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice. Methods: Kunming mice were randomly divided into five groups: normal group (NC), irradiation control group (IC), RTP1 low dose (200 mg/kg), middle dose (400 mg/kg) and high dose (800 mg/kg) groups. RTP1 was adminstered by the gastric route for 14 d, mice in the NC and IC groups being given by 0.9% sodium chloride solution in the same way. The mice in all groups except NC group were irradiated with 2.0 Gy $^{60}Co{\gamma}$-ray on the fourteenth day. Immune indives of non-specific immune function, cellular immunity and humoral immunity were assessed at the 24th hour after radiation. Results: Compared with the IC group, the spleen index, thymus index, rate of carbon clearance, phagocytic function of macrophages, lymphocyte proliferation, hemolysin value of blood serum and NK activity were increased markedly (P < 0.05 or P < 0.05). Conclusion: RTP1 has an obvious protective effects on damage in ${\gamma}$-ray radiated mice.
Keywords
Polysaccharide of Rheum tanguticum; immune function; radiating damage; $^{60}Co{\gamma}$ Ray;
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1 Chen HL, Li DF, Chang BY, et al (2003). Effects of Chinese herbal polysaccharides on the immunity and growth performance of young broilers. Poult Sci, 82, 364-70.   DOI
2 Chen Q (1993). Experimental methods of Chinese traditional medicinal pharmacology. Beijing: People's Medical Publishing House.
3 Gao Y, Zhou S, Jiang W, et al (2003). Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest, 32, 201-15.   DOI   ScienceOn
4 He X, Niu X, Li J, et al (2012). Immunomodulatory activities of five clinically used Chinese herbal polysaccharides. J Exp Integr Med, 2, 15-27.
5 Hosseinimehr SJ (2007). Trends in the development of radioprotective agents. Drug Discov Today, 12, 794-805.   DOI   ScienceOn
6 Hu D, Ling X, Hu J, et al (1988). The effects of radiotherapy on the immune system of patients with nasopharyngeal carcinoma. British J Radiol, 61, 305-8.   DOI
7 Jagetia GC (2007). Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr, 40, 74-81.   DOI
8 Jiang MH, Zhu L, Jiang JG (2010). Immunoregulatory actions of polysaccharides from Chinese herbal medicine. Expert Opin Ther Targets, 14, 1367-402.   DOI   ScienceOn
9 Kim HM, Han SB, Lee KH, et al (2000). Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis. Arch Pharm Res, 23, 240-2.   DOI
10 Lan MB, Zhang YH, Zheng Y, et al (2010). Antioxidant and immunomodulatory activities of polysaccharides from moxa (artemisia argyi) leaf. Food Sci Biotechnol, 19, 1463-9.   DOI
11 Lim TS, Na K, Choi EM, Chung JY, Hwang JK (2004). Immunomodulating activities of polysaccharides isolated from Panax ginseng. J Med Food, 7, 1-6.   DOI
12 Lin ZB (2005). Cellular and molecular mechanisms of immunomodulation by Ganoderma lucidum. J Pharmacol Sci, 99, 144-53.   DOI
13 Liu L, Yuan SF, Long Y, et al (2009). Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2, 4, 6-trinitrobenzene sulfonic acid. Int Immunopharmacol, 94, 1568-77.
14 Min J, Mei Q, Yang T, et al (2002). Effects of polysaccharide isolated from Angelica sinensis on proliferation of spleen lymphocytes in mice. Chinese J Cellular Molecular Immunol, 18, 502-3.
15 Ooi VE, Liu F (2000). Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem, 7, 715-29.   DOI
16 Ramberg JE, Nelson ED, Sinnott RA (2010). Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J, 9, 54.   DOI   ScienceOn
17 Schepetkin IA, Quinn MT (2006). Botanical polysaccharides: macrophage immunomodulation and therapeutic potential. Int Immunopharmacol, 6, 317-33.   DOI   ScienceOn
18 Tang WM, Chan E, Kwok CY, et al (2011). A review of the anticancer and immunomodulatory effects of Lycium barbarum fruit. Inflammopharmacology, DOI 10.1007/s10787-011-0107-3.
19 Tzianabos Q (2000). Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clin Microbiol Rev, 13, 4523-33.
20 Uh S, Lee SM, Kim HT, et al (1994). The effect of radiation therapy on immune function in patients with squamous cell lung carcinoma. Chest, 105, 132-7.   DOI
21 Wong KH, Connie KL, Cheung CK (2011). Immunomodulatory activities of mushroom sclerotial polysaccharides. Food Hydrocolloids, 25, 150-8.   DOI
22 Xie YX, An LG, Yang GW (2006). Immunomodulatory activity of botanical polysaccharides on macrophage. Int J Bio Macromolecules, 39, 179-84.   DOI   ScienceOn
23 Yang T, Jia M, Meng J, Wu H, Mei Q (2006). Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. Int J Biol Macromol, 39, 179-84.   DOI   ScienceOn
24 Yin Y, Fu W, Fu M, He G, Traore L (2007). The immune effects of edible fungus polysaccharides compounds in mice. Asia Pac J Clin Nutr, 16, 258-60.
25 Zhang R, Wand Z, Liu L, et al (2006). Efects of rheum tanguticum polysaccharides on ulcerative colitis induced by TNBS in mice. Chin J Clin Pharmacol Ther, 11, 995-8.
26 Zhu XL, Chen AF, Lin ZB (2007). Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice. J Ethnopharmacol, 111, 219-26.   DOI