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http://dx.doi.org/10.24304/kjcp.2022.32.1.125

Class duplication prescriptions in patients taking fixed-dose combination antihypertensives  

Koo, Hyunji (College of Pharmacy, Chung-Ang University)
Lee, Ji Won (College of Pharmacy, Chung-Ang University)
Choi, Ha Eun (College of Pharmacy, Chung-Ang University)
Je, Nam Kyung (College of Pharmacy, Pusan University)
Jeong, Kyeong Hye (College of Pharmacy, Chung-Ang University)
Publication Information
Korean Journal of Clinical Pharmacy / v.32, no.2, 2022 , pp. 125-132 More about this Journal
Abstract
Background: Fixed-dose combinations have the advantage of improving patient compliance, but may increase the risk of duplicate prescriptions. As the use of fixed-dose combination antihypertensives increases, it is necessary to investigate the current status of class duplication prescriptions (CDP) in patients taking fixed-dose combination antihypertensives in Korea and to identify factors associated with CDP. Methods: We conducted a retrospective observational study using nationally representative claim data. Hypertensive patients aged 20 years or older taking fixed-dose combination antihypertensives were extracted. Among these patients, patients with CDP were identified. A chi-square test was applied to determine the differences between patients with CDP and non-CDP. The associated factors of CDP were identified through multiple logistic regression. Results: Of the 74,165 patients who were prescribed fixed-dose combination antihypertensives, 426 patients (0.6%) with CDP were identified. The most common antihypertensive class associated with CDP was calcium channel blockers (194 patients, 45.5%), followed by angiotensin II receptor blockers (136 patients, 31.9%). Patients aged 75 years or older (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.02-3.52), chronic kidney disease (OR 4.45, 95% CI 2.15-8.25), chronic heart failure (OR 2.71, 95% CI 1.93-3.72), coronary artery disease (OR 2.22, 95% CI 1.60-3.03) and Medical Aid/Patriots and Veterans Insurance (OR 1.49, 95% CI 1.04-2.07) were significantly associated with increased CDP. Conclusions: The factors associated with CDP were the elderly, comorbidities, and low socioeconomic status. Since CDP can result in negative clinical outcomes, active intervention by the pharmacist is warranted.
Keywords
Fixed-dose combination antihypertensives; class duplication prescriptions; calcium channel blockers; angiotensin II receptor blockers;
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