Quercetin-3-O-β-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells |
Park, Jin-Young
(Department of Pharmacology, College of Medicine, Kangwon National University)
Lim, Man-Sup (Department of Pharmacology, College of Medicine, Kangwon National University) Kim, Song-In (Department of Pharmacology, College of Medicine, Kangwon National University) Lee, Hee Jae (Department of Pharmacology, College of Medicine, Kangwon National University) Kim, Sung-Soo (Department of Pharmacology, College of Medicine, Kangwon National University) Kwon, Yong-Soo (College of Pharmacy, Kangwon National University) Chun, Wanjoo (Department of Pharmacology, College of Medicine, Kangwon National University) |
1 | Cho, S. G. and Choi, E. J. (2002) Apoptotic signaling pathways: caspases and stress-activated protein kinases. J. Biochem. Mol. Biol. 35, 24-27. |
2 | Jagtap, S., Meganathan, K., Wagh, V., Winkler, J., Hescheler, J. and Sachinidis, A. (2009) Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases. Curr. Med. Chem. 16, 1451-1462. DOI |
3 | Kim, S. Y., Park, J. Y., Park, P. S., Bang, S. H., Lee, K. M., Lee, Y. R., Jang, Y. H., Kim, M. J., Chun, W., Heo, M. Y. and Kwon, Y. S. (2014) Flavonoid Glycosides as Acetylcholinesterase Inhibitors from the Whole Plants of Persicaria thunbergii. Nat. Prod. Sci. 20, 191-195. |
4 | Kim, Y. J., Shin, Y., Lee, K. H. and Kim, T. J. (2012) Anethum graveloens flower extracts inhibited a lipopolysaccharide-induced inflammatory response by blocking iNOS expression and activity in macrophages. Biosci. Biotechnol. Biochem. 76, 1122-1127. DOI |
5 | Kwon, Y. S., Kim, S. S., Sohn, S. J., Kong, P. J., Cheong, I. Y., Kim, C. M. and Chun, W. (2004) Modulation of suppressive activity of lipopolysaccharide-induced nitric oxide production by glycosidation of flavonoids. Arch. Pharm. Res. 27, 751-756. DOI |
6 | Lee, J. W., Bae, C. J., Choi, Y. J., Kim, S. I., Kim, N. H., Lee, H. J., Kim, S. S., Kwon, Y. S. and Chun, W. (2012) 3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-kappaB Activation in BV2 Microglial Cells. Korean J. Physiol. Pharmacol. 16, 107-112. DOI |
7 | Fan, D., Zhao, Y., Zhou, X., Gong, X. and Zhao, C. (2014) Simultaneous determination of esculetin, quercetin-3-O--D-glucuronide, quercetin-3-O--D-glucuronopyranside methyl ester and quercetin in effective part of Polygonum perfoliatum L. using high performace liquid chromatography. Pharmacogn. Mag. 10, 359-366. DOI |
8 | Guha, M. and Mackman, N. (2001) LPS induction of gene expression in human monocytes. Cell. Signal. 13, 85-94. DOI |
9 | Guo, J., Du, L., Shang, E., Li, T., Liu, Y., Qian, D., Tang, Y. and Duan, J. (2015) Conjugated metabolites represent the major circulating forms of Abelmoschus manihot in vivo and show an altered pharmacokinetic profile in renal pathology. Pharm. Biol. 54, 595-603. |
10 | Hertog, M. G., Feskens, E. J., Hollman, P. C., Katan, M. B. and Kromhout, D. (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007-1011. DOI |
11 | Hou, L., Zhou, B., Yang, L. and Liu, Z. L. (2004) Inhibition of free radical initiated peroxidation of human erythrocyte ghosts by flavonols and their glycosides. Org. Biomol. Chem. 2, 1419-1423. DOI |
12 | Yamazaki, S., Miyoshi, N., Kawabata, K., Yasuda, M. and Shimoi, K. (2014) Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking -adrenergic signaling. Arch. Biochem. Biophys. 557, 18-27. DOI |
13 | Ip, Y. T. and Davis, R. J. (1998) Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development. Curr. Opin. Cell Biol. 10, 205-219. DOI |
14 | Itharat, A. and Hiransai, P. (2012) Dioscoreanone suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW264.7 macrophages by NF-kappaB and ERK1/2 signaling transduction. J. Cell. Biochem. 113, 3427-3435. DOI |
15 | Lee, J. W., Kim, N. H., Kim, J. Y., Park, J. H., Shin, S. Y., Kwon, Y. S., Lee, H. J., Kim, S. S. and Chun, W. (2013) Aromadendrin Inhibits Lipopolysaccharide-Induced Nuclear Translocation of and Phosphorylation of JNK in RAW264.7 Macrophage Cells. Biomol. Ther. (Seoul) 21, 216-221. DOI |
16 | Vo, V. A., Lee, J. W., Chang, J. E., Kim, J. Y., Kim, N. H., Lee, H. J., Kim, S. S., Chun, W. and Kwon, Y. S. (2012) Avicularin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Suppressing ERK Phosphorylation in RAW264.7 Macrophages. Biomol. Ther. (Seoul) 20, 532-537. DOI |
17 | Vo, V. A., Lee, J. W., Park, J. H., Kwon, J. H., Lee, H. J., Kim, S. S., Kwon, Y. S. and Chun, W. (2014) N-(p-Coumaryol)-Tryptamine Suppresses the Activation of JNK/c-Jun Signaling Pathway in LPS-Challenged RAW264.7 Cells. Biomol. Ther. (Seoul) 22, 200-206. DOI |
18 | Wang, M., Liu, J. R., Gao, J. M., Parry, J. W. and Wei, Y. M. (2009) Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats. J. Agric. Food Chem. 57, 5106-5112. DOI |
19 | Wang, W. H., Gregori, G., Hullinger, R. L. and Andrisani, O. M. (2004) Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression. Mol. Cell. Biol. 24, 10352-10365. DOI |
20 | Lee, Y. J., Kim, S., Lee, S. J., Ham, I. and Whang, W. K. (2009) Antioxidant activities of new flavonoids from Cudrania tricuspidata root bark. Arch. Pharm. Res. 32, 195-200. DOI |
21 | Messer, J. G., Hopkins, R. G. and Kipp, D. E. (2015) Quercetin Metabolites Up-Regulate the Antioxidant Response in Osteoblasts Isolated From Fetal Rat Calvaria. J. Cell. Biochem. 116, 1857-1866. DOI |
22 | O'Connell, M. A., Bennett, B. L., Mercurio, F., Manning, A. M. and Mackman, N. (1998) Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J. Biol. Chem. 273, 30410-30414. DOI |
23 | Ock, J., Kim, S. and Suk, K. (2009) Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells. Pharmacol. Res. 59, 414-422. DOI |
24 | Pocernich, C. B., Lange, M. L., Sultana, R. and Butterfield, D. A. (2011) Nutritional approaches to modulate oxidative stress in Alzheimer's disease. Curr. Alzheimer Res 8, 452-469. DOI |
25 | Rehman, M. U., Yoshihisa, Y., Miyamoto, Y. and Shimizu, T. (2012) The anti-inflammatory effects of platinum nanoparticles on the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. Inflamm. Res. 61, 1177-1185. DOI |
26 | Rushworth, S. A., Chen, X. L., Mackman, N., Ogborne, R. M. and O'Connell, M. A. (2005) Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. J. Immunol. 175, 4408-4415. DOI |
27 | Yoon, C. S., Kim, D. C., Ko, W. M., Kim, K. S., Lee, D. S., Kim, D. S., Cho, H. K., Seo, J., Kim, S. Y., Oh, H. C. and Kim, Y. C. (2014) Anti-neuroinflammatory Effects of Quercetin-3-O-glucuronide Isolated from the Leaf of Vitis labruscana on LPS-induced Neuroinflammation in BV2 Cells. Kor. J. Pharmacogn. 45, 17-22. |
28 | Supinski, G. S., Ji, X. and Callahan, L. A. (2009) The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R825-R834. DOI |
29 | Sweet, M. J. and Hume, D. A. (1996) Endotoxin signal transduction in macrophages. J. Leukoc. Biol. 60, 8-26. DOI |
30 | Yang, H. H., Hwangbo, K., Zheng, M. S., Cho, J. H., Son, J. K., Kim, H. Y., Baek, S. H., Choi, H. C., Park, S. Y. and Kim, J. R. (2014) Quercetin-3-O--D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch. Pharm. Res. 37, 1219-1233. DOI |
31 | Zhang, W. Y., Lee, J. J., Kim, I. S., Kim, Y. and Myung, C. S. (2011) Stimulation of glucose uptake and improvement of insulin resistance by aromadendrin. Pharmacology 88, 266-274. DOI |
32 | Zhang, X., Hung, T. M., Phuong, P. T., Ngoc, T. M., Min, B. S., Song, K. S., Seong, Y. H. and Bae, K. (2006) Anti-inflammatory activity of flavonoids from Populus davidiana. Arch. Pharm. Res. 29, 1102-1108. DOI |
33 | Rietschel, E. T. and Brade, H. (1992) Bacterial endotoxins. Sci. Am. 267, 54-61. |