Antiviral Activity of Chrysin Derivatives against Coxsackievirus B3 in vitro and in vivo |
Song, Jae-Hyoung
(Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University)
Kwon, Bo-Eun (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University) Jang, Hongjun (College of Pharmacy, Ajou University) Kang, Hyunju (Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Cho, Sungchan (Targeted Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology) Park, Kwisung (Department of Microbiology, Chungcheongnam-Do Institute of Health and Environmental Research) Ko, Hyun-Jeong (Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University) Kim, Hyoungsu (College of Pharmacy, Ajou University) |
1 | Alirezaei, M., Flynn, C. T., Wood, M. R. and Whitton, J. L. (2012) Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host Microbe 11, 298-305. DOI |
2 | Baek, S. H., Jang, H. and Kim, H. (2015) Synthesis and biological evaluation of acetylcholinesterase inhibitor macakurzin C and its derivatives. Synlett 26, 1131-1134. DOI |
3 | Burke, S. J., Lu, D., Sparer, T. E., Masi, T., Goff, M. R., Karlstad, M. D. and Collier, J. J. (2014) NF-kappaB and STAT1 control CXCL1 and CXCL2 gene transcription. Am. J. Physiol. Endocrinol. Metab. 306, E131-149. DOI |
4 | Jaeckel, E., Manns, M. and Von Herrath, M. (2002) Viruses and diabetes. Ann. N. Y. Acad. Sci. 958, 7-25. |
5 | Kemball, C. C., Alirezaei, M., Flynn, C. T., Wood, M. R., Harkins, S., Kiosses, W. B. and Whitton, J. L. (2010) Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J. Virol. 84, 12110-12124. DOI |
6 | Kim, H., Lim, D., Shin, I. and Lee, D. (2014) Gram-scale synthesis of anti-pancreatic flavonoids ()-8-[1-(4'-hydroxy-3' methoxyphenyl) prop-2-en-1-yl]-chrysin and -galangin. Tetrahedron 70, 4738-4744. DOI |
7 | Kumar, S. and Pandey, A. K. (2013) Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal 2013, 162750. |
8 | Lee, D., Shin, I., Ko, E., Lee, K., Seo, S. Y. and Kim, H. (2014a) Total synthesis of acetylcholinesterase inhibitor macakurzin C. Synlett 25, 2794-2796. DOI |
9 | Lee, P. J., Shin, I., Seo, S. Y., Kim, H. and Kim, H. P. (2014b) Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP. Bioorg. Med. Chem. Lett. 24, 4845-4849. DOI |
10 | Lee, Y. H., Kim, S. H., Kim, Y., Lim, Y., Ha, K. and Shin, S. Y. (2012) Inhibitory effect of the antidepressant imipramine on NF-kappaBdependent CXCL1 expression in TNFalpha-exposed astrocytes. Int. Immunopharmacol. 12, 547-555. DOI |
11 | Lundgren, M., Darnerud, P. O., Blomberg, J., Friman, G. and Ilback, N. G. (2009) Sequential changes in serum cytokines reflect viral RNA kinetics in target organs of a coxsackievirus B infection in mice. J. Clin. Immunol. 29, 611-619. DOI |
12 | Song, J., Yeo, S. G., Hong, E. H., Lee, B. R., Kim, J. W., Kim, J., Jeong, H., Kwon, Y., Kim, H., Lee, S., Park, J. H. and Ko, H. J. (2014) Antiviral activity of hederasaponin B from hedera helix against enterovirus 71 subgenotypes C3 and C4a. Biomol. Ther. 22, 41-46. DOI |
13 | Park, J. H., Kim, D. S., Cho, Y. J., Kim, Y. J., Jeong, S. Y., Lee, S. M., Cho, S. J., Yun, C. W., Jo, I. and Nam, J. H. (2009) Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis. Vaccine 27, 1974-1983. DOI |
14 | Ramsingh, A. I. (1997) Coxsackieviruses and pancreatitis. Front. Biosci. 2, e53-62. |
15 | Schnitzler, P., Neuner, A., Nolkemper, S., Zundel, C., Nowack, H., Sensch, K. H. and Reichling, J. (2010) Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother. Res. 24 Suppl 1, S20-28. DOI |
16 | Tracy, S., Hofling, K., Pirruccello, S., Lane, P. H., Reyna, S. M. and Gauntt, C. J. (2000) Group B coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice. J. Med. Virol. 62, 70-81. DOI |
17 | Wang, J., Zhang, T., Du, J., Cui, S., Yang, F. and Jin, Q. (2014) Antienterovirus 71 effects of chrysin and its phosphate ester. PLoS One 9, e89668. DOI |
18 | Wilsky, S., Sobotta, K., Wiesener, N., Pilas, J., Althof, N., Munder, T., Wutzler, P. and Henke, A. (2012) Inhibition of fatty acid synthase by amentoflavone reduces coxsackievirus B3 replication. Arch. Virol. 157, 259-269. DOI |
19 | Wood, L. D., Farmer, A. A. and Richmond, A. (1995) HMGI(Y) and Sp1 in addition to NF-kappa B regulate transcription of the MGSA/GRO alpha gene. Nucleic Acids Res. 23, 4210-4219. DOI |
20 | Yajima, T. and Knowlton, K. U. (2009) Viral myocarditis: from the perspective of the virus. Circulation 119, 2615-2624. DOI |
21 | Yin, D., Li, J., Lei, X., Liu, Y., Yang, Z. and Chen, K. (2014) Antiviral activity of total flavonoid extracts from selaginella moellendorffii hieron against coxsackie virus B3 in vitro and in vivo. Evid. Based Complement. Alternat. Med. 2014, 950817. |
22 | Zaragoza, C., Saura, M., Padalko, E. Y., Lopez-Rivera, E., Lizarbe, T. R., Lamas, S. and Lowenstein, C. J. (2006) Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. Proc. Natl. Acad. Sci. U.S.A. 103, 19051-19056. DOI |
23 | Zhang, H. M., Ye, X., Su, Y., Yuan, J., Liu, Z., Stein, D. A. and Yang, D. (2010) Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J. Virol. 84, 8446-8459. DOI |
24 | Zhu, H., Zhang, Y., Ye, G., Li, Z., Zhou, P. and Huang, C. (2009) In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3. Biol. Pharm. Bull. 32, 68-73. DOI |