[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.4062/biomolther.2014.044

Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage

Kim, Ki Cheon (School of Medicine and Institute for Nuclear Science and Technology)
Piao, Mei Jing (School of Medicine and Institute for Nuclear Science and Technology)
Zheng, Jian (School of Medicine and Institute for Nuclear Science and Technology)
Yao, Cheng Wen (School of Medicine and Institute for Nuclear Science and Technology)
Cha, Ji Won (School of Medicine and Institute for Nuclear Science and Technology)
Kumara, Madduma Hewage Susara Ruwan (School of Medicine and Institute for Nuclear Science and Technology)
Han, Xia (School of Medicine and Institute for Nuclear Science and Technology)
Kang, Hee Kyoung (School of Medicine and Institute for Nuclear Science and Technology)
Lee, Nam Ho (Department of Chemistry, College of Natural Sciences, Jeju National University)
Hyun, Jin Won (School of Medicine and Institute for Nuclear Science and Technology)

Publication Information

Biomolecules & Therapeutics / v.22, no.4, 2014 , pp. 301-307 More about this Journal

Abstract

Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) irradiation. Fucodiphlorethol G attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in response to UVB irradiation. Fucodiphlorethol G suppressed the inhibition of human keratinocyte growth by UVB irradiation. Additionally, the wavelength of light absorbed by fucodiphlorethol G was close to the UVB spectrum. Fucodiphlorethol G reduced UVB radiation-induced 8-isoprostane generation and DNA fragmentation in human keratinocytes. Moreover, fucodiphlorethol G reduced UVB radiation-induced loss of mitochondrial membrane potential, generation of apoptotic cells, and active caspase-9 expression. Taken together, fucodiphlorethol G protected human keratinocytes against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging reactive oxygen species.

Keywords

Fucodiphlorethol G; Ultraviolet B; Mitochondria membrane potential; Reactive oxygen species; Human keratinocytes;

Citations & Related Records

Times Cited By KSCI : 1 (Citation Analysis)

Reference
Cited By KSCI

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