Effect of Ambroxol on Secretion, Production and Gene Expression of Mucin from Cultured Airway Epithelial Cells |
Lee, Hyun-Jae
(Department of Pharmacology, School of Medicine, Chungnam National University)
Lee, Su-Yel (Department of Pharmacology, School of Medicine, Chungnam National University) Cho, Kyoung-Rai (Department of Otorhinolaryngology, Sanggye Paik Hospital, College of Medicine, Inje University) Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College) Lee, Jae-Woo (LG Life Science) Bae, Heung-Seog (Department of Pharmacology, School of Medicine, Chungnam National University) Lee, Choong-Jae (Department of Pharmacology, School of Medicine, Chungnam National University) |
1 | Yuan-Chen Wu, D., Wu, R., Reddy, S. P., Lee, Y. C. and Chang, M. M. (2007) Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am. J. Pathol. 170, 20-32. DOI |
2 | Miyata, T., Kai, H., Saito, M., Okano, Y., Takahama, K., Nakagawa, M. and Kojima, S. (1986) Effects of ambroxol on pulmonary surfactant-analysis of the fatty acid composition of phosphatidylcholine in the sputum and normal respiratory tract fluid in rabbits. Nippon Yakurigaku Zasshi 88, 57-64. DOI |
3 | Mutschler, E. and Derendorf, H. (1995) Drug actions, pp. 410-411, CRC Press, Boca Raton, Florida. |
4 | Park, S. J., Kang, S. Y., Kim, N. S. and Kim, H. M. (2002) Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60cells. Immunopharmacol. Immunotoxicol. 24, 211-226. DOI |
5 | Rogers, D. F. and Barnes, P. J. (2006) Treatment of airway mucus hypersecretion. Ann. Med. 38, 116-125. DOI |
6 | Shao, M. X., Ueki, I. F. and Nadel, J. A. (2003) TNF-alpha converting enzyme mediated MUC5AC mucin expression in cultured human airway epithelial cells. Proc. Natl. Acad. Sci. USA. 100, 11618-11623. DOI |
7 | Stetinova, V., Herout, V. and Kvetina, J. (2004) In vitro and in vivo antioxidant activity of ambroxol. Clin. Exp. Med. 4, 152-158. DOI |
8 | Takeyama, K., Dabbagh, K., Shim, J. J., Dao-Pick, T., Ueki, I. F. and Nadel, J. A. (2000) Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J. Immunol. 164, 1546-1552. DOI |
9 | Takeyama, K., Dabbagh, K., Lee, H., Agusti, C., Lausier, J. A., Ueki, I. F., Grattan, K. M. and Nadel, J. A. (1999) Epidermal growth factor system regulates mucin production in airways. Proc. Natl. Acad. Sci. USA. 96, 3081-3086. DOI |
10 | Voynow, J. A. and Rubin, B. K. (2009) Mucins, mucus, and sputum. Chest 135, 505-512. DOI |
11 | Wasano, K., Kim, K. C., Niles, R. M. and Brody, J.S. (1988) Membrane differentiation markers of airway epithelial secretory cells. J. Histochem. Cytochem. 36, 167-178. DOI ScienceOn |
12 | Beeh, K. M., Beier, J., Esperester, A. and Paul, L. D. (2008) Anti-inflammatory properties of ambroxol. Eur. J. Med. Res. 13, 557-562. |
13 | Gordon, J. L. (1986) Extracellular ATP: effects, sources and fate. Biochem. J. 233, 309-319. |
14 | Heo, H. J., Lee, H. J., Yoon, C. S., Lim, S. P., Seok, J. H., Seo, U. K. and Lee, C. J. (2005) Effects of ambroxol, S-carboxymethylcysteine, dextromethorphan and noscapine on mucin release from airway goblet cells. Korean J. Physiol. Pharmacol. 9, 323-326. 과학기술학회마을 |
15 | Hewson, C. A., Edbrooke, M. R. and Johnston, S. L. (2004) PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J. Mol. Biol. 344, 683-695. DOI |
16 | Kim, K. C., McCracken, K., Lee, B. C., Shin, C. Y., Jo, M. J., Lee, C. J. and Ko, K. H. (1997) Airway goblet cell mucin: its structure and regulation of secretion. Eur. Respir. J. 11, 2644-2649. |
17 | Li, J. D., Dohrman, A. F., Gallup, M., Miyata, S., Gum, J. R., Kim, Y. S., Nadel, J. A., Prince, A. and Basbaum, C. B. (1997) Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc. Natl. Acad. Sci. USA. 94, 967-972. DOI |
18 | Ko, K. H., Lee, C. J., Shin, C. Y., Jo, M. J. and Kim, K. C. (1999) Inhibition of mucin release from airway goblet cells by polycationic peptides. Am. J. Physiol. 277, L811-L815. |
19 | Lazarowski, E. R. and Boucher, R. C. (2009) Purinergic receptors in airway epithelia. Curr. Opin. Pharmacol. 9, 262-267. DOI |
20 | Lee, C. J., Paik, S. H., Ko, K. H. and Kim, K. C. (2002) Effects of polycationic peptides on mucin release from airway goblet cells: relationship between polymer size and activity. Inflamm. Res. 51, 490-494. DOI |
21 | Aliperta, A., Bellissimo, U., Turco, D. and Antinolfi, G. (1986) Normalization of bronchial exocrine pathology after endobronchial treatment with ambroxol. Int. J. Tissue React. 8, 167-174. |