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http://dx.doi.org/10.4062/biomolther.2008.16.4.431

A Comparison of Gene Expression Profiles between Primary Human AML Cells and Therapy-related AML Cells  

Kim, Young-Hun (School of Life Science and Biotechnology, Kyungpook National University)
Kim, Hyung-Soo (School of Life Science and Biotechnology, Kyungpook National University)
Hwang, Jun-Mo (School of Life Science and Biotechnology, Kyungpook National University)
Lee, Jin-Seok (School of Life Science and Biotechnology, Kyungpook National University)
Kim, Seong-Gon (School of Life Science and Biotechnology, Kyungpook National University)
Park, So-Young (Environmental Toxico-Genomic&Proteomic Center, College of Medicine, Korea University)
Chang, Kyu-Tae (National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology)
Kim, Kil-Soo (Department of Veterinary Medicine, Kyungpook National University)
Ryoo, Zae-Young (School of Life Science and Biotechnology, Kyungpook National University)
Lee, Sang-Gyu (School of Life Science and Biotechnology, Kyungpook National University)
Publication Information
Biomolecules & Therapeutics / v.16, no.4, 2008 , pp. 431-436 More about this Journal
Abstract
To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change ($\geq$ 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. Of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categories (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.
Keywords
Therapy-related AML; Gene expression; SAGE;
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