Browse > Article
http://dx.doi.org/10.4062/biomolther.2008.16.3.231

Anti-Inflammatory, Anti-Angiogenic and Anti-Nociceptive Activities of 4-Hydroxybenzaldehyde  

Lim, Eun-Ju (College of Pharmacy, Sookmyung Women's University)
Kang, Hyun-Jung (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Jung, Hyun-Joo (College of Pharmacy, Sookmyung Women's University)
Kim, Kyung-Hoon (College of Pharmacy, Sookmyung Women's University)
Lim, Chang-Jin (Division of Life Sciences and Research Institute of Life Sciences, Kangwon National University)
Park, Eun-Hee (College of Pharmacy, Sookmyung Women's University)
Publication Information
Biomolecules & Therapeutics / v.16, no.3, 2008 , pp. 231-236 More about this Journal
Abstract
The current work was designed to assess novel pharmacological activities of 4-hydroxybenzaldehyde (HD), a major phenolic constituent of various natural products of plant origin, such as Gastrodia elata Blume. HD exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. HD also displayed an inhibitory effect in acetic acid-induced permeability in mice. Anti-nociceptive activity of HD was convinced using the acetic acid-induced writhing test in mice. HD was able to suppress production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. HD also diminished the reactive oxygen species (ROS) level elevated in the LPS-activated macrophages. In brief, HD exhibits anti-angiogenic, anti-inflammatory and anti-nociceptive activities possibly via down-regulating iNOS and/or COX-2, which may be partly responsible for pharmacological efficacies of various natural products.
Keywords
Anti-angiogenic; Anti-inflammatory; Anti-nociceptive; Cyclooxygenase-2; 4-hydroxybenzaldehyde; Inducible nitric oxide synthase; Nitric oxide; RAW264.7; Reactive oxygen species;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
연도 인용수 순위
1 Sherman, M. P., Aeberhard, E. E. and Wong, V. Z., Griscavage, J. M. and Ignarro, L. J. (1993). Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191, 1301-1308   DOI   ScienceOn
2 Whittle, B. A. (1964). The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Brit. J. Pharmacol. Chemother. 22, 246-253   DOI   ScienceOn
3 Ahn, E. K., Jeon, H. J., Lim, E. J., Jung, H. J., Park, E. H. (2007) Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume. J. Ethnopharmacol. 110, 476-482   DOI   ScienceOn
4 Franzotti, E. M., Santos, C. V. F., Rodrigues, H. M. S. L., Mourao, R. H. V. and Andrade, M. R. (2002). Anti-inflammatory, analgesic and acute toxicity of Sida cardiafolia L. J. Ethnopharmacol. 72, 59-65
5 Ha, J. H., Lee, D. U., Lee, J. T., Kim, J. S., Yong, C. S., Kim, J. A., Ha, J. S. and Huh, K. (2000). 4-Hydroxybenzaldehyde from Gastrodia elata Bl. is active in the antioxidation and GABAergic neuromodulation of rat brain. J. Ethnopharmacol. 73, 329-333   DOI   ScienceOn
6 Ha, J. H., Shin, S. M., Lee, S. K., Kim, J. S., Shin, U. S., Huh, K., Kim, J. A., Yong, C. S., Lee, N. J. and Lee, D. U. (2001). In vitro effects of hydroxybenzaldehydes from Gastrodia elata and their analogues on GABAergic neurotransmission, and a structure-activity correlation. Planta Med. 67, 877-880   DOI   ScienceOn
7 Lim, E. J., Kang, H. J., Jung, H. J., Song, Y. S., Lim, C. J., Park, E. H. (2008) Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillin in ICR mice. Biomol. Ther. 16, 132-136   DOI   ScienceOn
8 Jachak, S. M. (2006). Cyclooxygenase inhibitory natural products: current status. Curr. Med. Chem. 13, 659-678   DOI   ScienceOn
9 Jung, J. W., Yoon, B. H., Oh, H. R., Ahn, J. H., Kim, S. Y., Park, S. Y. and Ryu, J. H. (2006). Anxiolytic-like effects of Gastrodia elata and its phenolic constituents in mice. Biol. Pharm. Bull. 29, 261-265   DOI   ScienceOn
10 Kim, H. J., Hwang, I. K., Won, M. H. (2007) Vanillin, 4-hydroxy-benzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. Brain Res. 1181, 130-141   DOI   ScienceOn
11 Olajide, O. A., Awe, S. O., Makinde, J. M., Ekhelar, A. I., Olusola, A., Morebise, O. and Okpako, D. T. (2000). Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. J. Ethnopharmacol. 71, 179-186   DOI   ScienceOn
12 Royall, J. A. and Ischiropoulos, H. (1993). Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular $H_2O_2$ in cultured endothelial cells. Arch. Biochem. Biophys. 302, 348-355   DOI   ScienceOn
13 Vogel, H. G. and Vogel, W. H. (1997). Drug Discovery and Evaluations, Pharmacological Assays. Springer, Berlin, pp. 402-403
14 Singh, V. K., Mehrotra, S., Narayan, P., Pandey, C. M. and Agarwal, S. S. (2000). Modulation of autoimmune diseases by nitric oxide. Immunol. Res. 22, 1-19   DOI   ScienceOn
15 Chesrown, S. E., Monnier, J., Visner, G. and Nick, H. S. (1994). Regulation of inducible nitric oxide synthase mRNA levels by LPS, INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 200, 126-134   DOI   ScienceOn
16 Tong, Y., Zhang, X., Zhao, W., Zhang, Y., Lang, J., Shi, Y., Tan, W., Li, M., Zhang, Y., Tong, L., Lu, H., Lin, L. and Ding, J. (2004). Anti-angiogenic effects of Shiraiachrome A, a compound isolated from a Chinese folk medicine used to treat rheumatoid arthritis. Eur. J. Pharmacol. 494, 101-109   DOI   ScienceOn
17 Lim, E. J., Kang, H. J., Jung, H. J., Park, E. H. (2007) Antiangiogenic, anti-inflammatory and anti-nociceptive activity of 4-hydroxybenzyl alcohol. J. Pharm. Pharmacol. 59, 1235-1240   DOI   ScienceOn
18 Song, Y. S., Kim, S. H., Sa, J. H., Jin, C., Lim, C. J. and Park, E. H. (2003). Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J. Ethnopharmacol. 88, 113-116   DOI   ScienceOn