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http://dx.doi.org/10.4062/biomolther.2008.16.3.179

The Efflux Transport of Choline through Blood-Brain Barrier is Inhibited by Alzheimer's Disease Therapeutics  

Lee, Na-Young (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University)
Kang, Young-Sook (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Sookmyung Women's University)
Publication Information
Biomolecules & Therapeutics / v.16, no.3, 2008 , pp. 179-183 More about this Journal
Abstract
In the present study, we examined the effects of several therapeutics of Alzheimer's disease, such as donepezil hydrochloride, tacrine and $\alpha$-phenyl-n-tert-butyl nitrone (PBN) on choline efflux from brain to circulating blood. The brain-to-blood efflux of [$^3H$]choline in rats was significantly inhibited by tacrine and PBN. Also the [$^3H$]choline efflux was reduced by tacrine and donepezil hydrochloride in the TR-BBB cells, in vitro the blood-brain barrier (BBB) model. These results suggest that these drugs may influence choline efflux transport from brain to blood and regulate the choline level in brain resulting in the increase of acetylcholine synthesis.
Keywords
Blood-brain barrier; Choline transport; Alzheimer's disease therapeutics; in vivo brain efflux index method; TR-BBB cells;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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