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http://dx.doi.org/10.4062/biomolther.2008.16.2.137

Effects of Picrorrhiza Rhizoma on Acute Inflammation in Mice  

Lee, Hyeung-Sik (Department of Herbal Biotechnology, Daegu Haany University)
Ku, Sae-Kwang (Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Development Team for the New Drug of Oriental Medicine (BK21 Program),Daegu Haany University)
Publication Information
Biomolecules & Therapeutics / v.16, no.2, 2008 , pp. 137-140 More about this Journal
Abstract
The effects of Picrorrhiza Rhizoma (PR) aqueous extracts were observed on xylene-induced acute inflammation. The xylene was topically applied 60 min after administration of 500, 250 and 125 mg/kg of PR extracts, and all animals were sacrificed 2 hrs after xylene application. The changes on ear weights, histolopathological analyses of ear were evaluated as compared with indomethacin and dexamethasone 15 mg/kg treated groups - well known anti-inflammatory agents. Xylene application resulted in marked increases in induced ear weights as compared with intact control ear. Severe vasodilation, edematous changes of ear skin and increase in the thickness of the ear tissues as acute inflammation were detected in xylene-treated control ears at histopathological observation. However, these xylene-induced acute inflammatory changes were dosedependently decreased by oral treatment of PR extracts. Therefore, it is concluded that PR extracts has favorable anti-inflammatory effects on xylene-applicated acute ear inflamed mice.
Keywords
Picrorrhiza Rhizoma; extracts; acute inflammation; xylene; histology; mouse;
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Times Cited By Web Of Science : 3  (Related Records In Web of Science)
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1 De La Puerta, R., Martinez, E., Bravo, L. and Ahumada, M. C. (1996). Effect of silymarin on different acute inflammation models and on leukocyte migration. J. Pharm. Pharmacol. 48, 968-970   DOI   ScienceOn
2 Habashy, R. R., Abdel-Naim, A. B., Khalifa, A. E. and Al-Azizi, M. M. (2005). Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacol. Res. 51, 95-105   DOI   ScienceOn
3 Hosseinzadeh, H. and Younesi, H. M. (2002). Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2, 7-12   DOI
4 Kou, J., Ni, Y., Li, N., Wang, J., Liu, L. and Jiang, Z. H. (2005). Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens. Biol. Pharm. Bull. 28, 176-180   DOI   ScienceOn
5 Lee, H. S., Ahn, H. C. and Ku, S. K. (2006a). Hypolipemic effect of water extracts of Picrorrhiza rhizoma in PX-407 induced hyperlipemic ICR mouse model with hepatoprotective effects: A prevention study. J. Ethnopharmacol. 105, 380-386   DOI   ScienceOn
6 Hosseinzadeh, H., Haddadkhodaparast, M. H. and Arash, A. R. (2003). Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats. Phytother. Res. 17, 422-425   DOI   ScienceOn
7 Al-Majed, A. A., Khattab, M., Raza, M., Al-Shabanah, O. A. and Mostafa, A. M. (2003). Potentiation of diclofenac-induced antiinflammatory response by aminoguanidine in carrageenaninduced acute inflammation in rats: the role of nitric oxide. Inflamm. Res. 52, 378-382   DOI
8 Amin, A. R., Vyas, P., Attur, M., Leszczynska-Piziak, J., Patel, I. R., Weissmann, G. and Abramson, S. B. (1995). The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA 92, 7926-7930   DOI   ScienceOn
9 Senthil Kumar, S. H., Anandan, R., Devaki, T. and Santhosh Kumar, M. (2001). Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats. Fitoterapia 72, 402-405   DOI   ScienceOn
10 Jagetia, G. C. and Baliga, M. S. (2004). The evaluation of nitric oxide scavenging activity of certain Indian medicinal plants in vitro: a preliminary study. J. Med. Food 7, 343-348   DOI
11 Kim, H. D., Cho, H. R., Moon, S. B., Shin, H. D., Yang, K. J., Park, B. R., Jang, H. J., Kim, L. S., Lee, H. S. and Ku, S. K. (2007). Effects of beta-glucan from Aureobasidium pullulans on acute inflammation in mice. Arch. Pharm. Res. 30, 323- 328   과학기술학회마을   DOI   ScienceOn
12 Jeena, K. J., Joy, K. L. and Kuttan, R. (1999). Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on Nnitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 136, 11-16   DOI   ScienceOn
13 Joy, K. L. and Kuttan, R. (1999). Anti-diabetic activity of Picrorrhiza kurroa extract. J. Ethnopharmacol. 67, 143-148   DOI   ScienceOn
14 Joy, K. L., Rajeshkumar, N. V., Kuttan, G. and Kuttan, R. (2000). Effect of Picrorrhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice. J. Ethnopharmacol. 71, 261-266   DOI   ScienceOn
15 Lee, H. S., Woo, S. J. and Ku, S. K. (2008). Hypolipemic and hepatoprotective effects of picrorrhiza rhizome in high fat diet supplied mice. A prevention study. Biomolecules & Therapeutics 16, 46-53   과학기술학회마을   DOI   ScienceOn
16 Lee, H. S., Yoo, C. B. and Ku, S. K. (2006b). Hypolipemic effect of water extracts of Picrorrhiza rhizoma in high fat diet treated mouse. Fitoterapia, 77, 579-584   DOI   ScienceOn
17 Rotelli, A. E., Guardia, T., Juarez, A. O., de la Rocha, N. E. and Pelzer, L. E. (2003). Comparative study of flavonoids in experimental models of inflammation. Pharmacol. Res. 48, 601-606   DOI   ScienceOn
18 Mehrotra, R., Rawat, S., Kulshreshtha, D. K., Patnaik, G. K. and Dhawan, B. N. (1990). In vitro studies on the effect of certain natural products against hepatitis B virus. Indian J. Med. Res. 92, 133-138
19 Ojewole, J. A. (2005). Antinociceptive, anti-inflammatory and antidiabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J. Ethnopharmacol. 99, 13-19   DOI   ScienceOn
20 Ramprasath, V. R., Shanthi, P. and Sachdanandam, P. (2006). Immunomodulatory and anti-inflammatory effects of Semecarpus anacardium LINN. Nut milk extract in experimental inflammatory conditions. Biol. Pharm. Bull. 29, 693-700   DOI   ScienceOn