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Inhibition of Collagenase by Anti-inflammatory Synthetic Flavones  

Park Hae-Il (College of Pharmacy, Kangwon National University)
Sin Bo-Young (College of Pharmacy, Kangwon National University)
Kim Hyun-Pyo (College of Pharmacy, Kangwon National University)
Publication Information
Biomolecules & Therapeutics / v.14, no.1, 2006 , pp. 36-39 More about this Journal
Abstract
Some flavones/flavonols were previously found to inhibit collagenase. To establish a therapeutic potential for skin inflammation, twenty-three synthetic flavone derivatives were examined for their inhibitory potential against collagenase from Clostridium histolyticum. From the results, it was found that most of them having various hydroxyl, methoxyl, methylsulfuryl and/or chloro substitution(s) on A- and B-rings were not efficient collagenase inhibitors. Among the synthetic flavones tested, only two synthetic derivatives, 3',4'-dihydroxyflavone and 5-hydroxy-4'-methoxyflavone, weakly inhibited bacterial collagenase (13-29% inhibition at 50-100 ${\mu}M$).
Keywords
flavonoid; collagenase; matrix metalloproteinase; skin inflammation;
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Times Cited By KSCI : 1  (Citation Analysis)
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