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Single Oral Toxicity Study of 3-Methoxy-6-Allylthiopyridazine in Rats  

Jung, Ki-Hwa (College of Pharmacy, Duksung Women's University)
Publication Information
Biomolecules & Therapeutics / v.13, no.2, 2005 , pp. 123-126 More about this Journal
Abstract
The single dose toxicity of 3-methoxy-6-allylthiopyridazine (K-6) was studied with Sprague-Dawley rats. K-6 was administered orally with dosages of 4.0, 3.0, 1.5, 1.0, 0.5, 0.25 and 0.1 g/kg to the rats. We observed daily the number of death, clinical signs, body weights and gross findings. All rats (6) were dead within a day after administration when doses of 4.0and 3.0 g/kg were administered. When dose of 2.0 g/kg was administered, 2 rats among 3 rats were dead. Any significant toxicity below 1.5g/kg of K6 was not observed when the different doses of 1.5, 1.0, 0.5, 0.25 and 0.1 g/kg were administered to 6 rats respectively.
Keywords
3-Methoxy-6-allythiopyridazine; single oral toxicity; rats;
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