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Diabetes, Glucose Transport and Hypoglycaemic Agents  

Khil, Lee-Yong (Faculty of Medicine, University of Calgary)
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Biomolecules & Therapeutics / v.12, no.4, 2004 , pp. 202-208 More about this Journal
Diabetes mellitus is a complex metabolic derangement with hyperglycaemia being the most characteristic symptom of diabetes. Hyperglycaemia can be caused by an increase in the rate of glucose production by the liver or by a decrease in the rate of glucose use by peripheral tissues. Impaired glucose transport is one of the major factors contributing to insulin resistance in type 2 diabetic patients. The ability of insulin to mediate tissue glucose uptake is a critical step in maintaining glucose homeostasis and in clearing the post-prandial glucose load. Glucose transport is mediated by specific carriers called glucose transporters (GLUTs). In this article, the functional importance and molecular mechanisms of insulin-induced glucose transport and development of hypoglycaemic agents which increase glucose transport are reviewed.
diabetes; glucose transport; hypoglycemic agent; insulin; phophatitylinositol 3-kinase; TC10;
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