Browse > Article

Tyrosinase Inhibitory Activity of 80 Plant Extracts (II)  

Kim, Soo-Jin (College of Pharmacy, Kangwon National University)
Heo, Moon-Young (College of Pharmacy, Kangwon National University)
Son, Kun-Ho (Dept. Food Nutrition, Andong National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Publication Information
Biomolecules & Therapeutics / v.11, no.1, 2003 , pp. 5-7 More about this Journal
Abstract
The purpose of this study was to evaluate tyrosinase inhibitory activity of plant for extracts for cosmetic use. When 80 plant extracts were tested, the methanol extracts of Allium thunbergi, Asparagus oligoclonos, Ixeris dentate, Salvia plebeia, Sophora flavescens and Sophora japonica showed more than 30% inhibition of mushroom tyrosinase activity at 100 $\mu\textrm{g}$/mL. Although less active than the reference compound, kojic acid ($IC_{50}$=7.0-16.3 $\mu\textrm{g}$/mL), these plant extracts may be used as tyrosinase inhibitors in cosmetics.
Keywords
tyrosinase; plant; skin whitening; Salvia plebeia; Sophora flavescens;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Choi, S.-S., Noh, H.-S., Cho, S.-H. and Kong, K.H. (2001).Screening of inhibitors against tyrosinase activity from naturalproducts. Yakhak Hoeji 45, 522-528
2 Ha, T.J., Yang, M.S., Jang, D.S., Choi, S.U. and Park, K.H.(2001). Inhibitory activities of flavanone derivatives isolatedfrom Sophora fIavescens for melanogenesis. Bull. KoreanChem. Soc. 22, 97-99
3 Lee, K.T., Kim, B.J., Kim, J.H., Heo, M.Y. and Kim, H.P. (1997).Biological screening of 100 plant extracts for cosmetic use (I):inhibitory activities of tyrosinase and DOPA auto-oxidationInt. J. Cosmetic Sci. 19, 291-298   DOI   ScienceOn
4 Lee, S.-H., Park, J.S., Kim, S.Y., Kim, J.J. and Chung, S.R.(1997). The screening of the inhibitory compounds on tyrosi-nase activity from the natural product. Yakhak Hoeji 41, 456-461
5 Sanchez-Ferrer, A., Rodriguez-Lopez, J.N., Garcia-Canova, F.and Garda-Carmona, F. (1995). Tyrosinase: a comprehensivereview of its mechanism. Biochim. Biophys. Acta 1247, 1-11   DOI   ScienceOn
6 Vanni, A., Gastaldi, D. and Giunatu, G. (1990). Kinetic investiga-tion on the double enzymatic activity of the mushroom tyrosi-nase. Annai di Chimica 80, 35-60
7 Chi, B.W., Lee, B.H., Kang, K.J., Lee, E.S. and Lee, N.H. (1998).Screening of the tyrosinase inhibitors from marine algae andmedicinal plants. Kor. J. Pharmacogn. 29, 237-242