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Local Irritation Test of HM10411 (rhG-CSF) in Rabbits  

차신우 (한국화학연구원 부설 안전성평가연구소)
한정희 (한국화학연구원 부설 안전성평가연구소)
김충용 (한국화학연구원 부설 안전성평가연구소)
서정은 (한국화학연구원 부설 안전성평가연구소)
김종춘 (전남대학교 수의과대학)
권세창 (한미약품공업주식회사)
Publication Information
Biomolecules & Therapeutics / v.10, no.3, 2002 , pp. 170-174 More about this Journal
Abstract
The local irritation study (skin and occular irritation tests) of HM10411, a rhG-CSF (recombinant human granulocyte-colony stimulating factor) was carried out in New Zealand White rabbits. HM10411 was applied to the bare skin at a dose of 2.5 mg/rabbit (5.0 mg/ml, 0.5 ml) and to the conjunctival sac of eye at a dose of 0.5 mg/rabbit (5.0 mg/ml, 0.1 ml) , respectively. In this study, there were no clinical signs which were related to HM10411 compared with those of control group. From above results, HM10411 has not any irritating activity to skin and eye in rabbits.
Keywords
HM10411; rhG-CSF; Local irritation; Rabbit;
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