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Manganese-induced Oxidative Stress in Nucleus Accumbens of Rat Brain  

Hyun Chul Koh (한양대학교 의과대학 약리학 교실)
Hyun A Shin (한양대학교 의과대학 예방의학교실)
Soo-jin Lee (한양대학교 의과대학 산업의학교실)
Publication Information
Biomolecules & Therapeutics / v.10, no.1, 2002 , pp. 25-31 More about this Journal
Abstract
This study was carried out to identify the effect of oxidative stress on the pathogenesis of manganese intoxication. Five rats in experimental group were given with $MnCl_2$intraperitoneally for 4 weeks(4 mg/kg once daily 5 days per week) and another five rats for control group were given with normal saline. In experimental group, manganese concentrations increased significantly in nucleus accumbens by 142% (p<0.05), SOD activities increased significantly by 124%(p<0.01), and MDA concentrations increased significantly 148%(p<0.05) compared with control group. Among fatty acids, total n-6 polyunsaturated fatty acids(PU) increased significantly by 231%(p<0.05) compared with control group. Arachidonic acids(AA) increased by 224%(p<0.05), and these increase were composed mostly of n-6 polyunsaturated fatty acids(PUFA). Among n-3 PUFAs except linolenic acids, eicosapentanolc acid(EPA) decreased significantly by 38%(p 0.01) and docosahexanoic acids(DHA) decreased by 30% p<0.05) compared with control group. Our results suggest that the oxygen free radicals produced by manganese may cause compositional changes of fBtty acids in nucleus accumbens of the rat. Characteristics of fatty acids compositional changes by manganese were the decrease of EPAs and DHAs(n-3 PUFAs), and increase of AAs(n-6 PUFAs). These changes with the increase of MDA, suggest that manganese neurotokxcity is caused by lipid perokidation mediated with oxygen free radicals, especially superoxide radicals.
Keywords
Fatty acid; Manganese; Malondialdehyde; Nucleus accumbens; Oxidative stress; Superoxide dismutase;
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1 National Institute for Occupational Safety and Hcalth (NIOSH). (1997). Pocket guide to chemical hazards. US Department of Health and Human Services, Centers for Disease Control and Prevention. Cincinnati. OH: NIOSH Publication
2 Osterode, W. and Ulberth, F. (2000). Increased concentration of arachidonic acid in erythrocyte membrains in chronically lead-exposed men. J. Toxicol. Environ. Health, part A 59, 87-95
3 Relton, J. K., Strijbos, P. J. L. M., Cooper, A. L., Rothwell, N. J. (1993). Dietary n-3 fatty acids inhibit ischemic and excitotoxic brain damage in the rat. Brain Res. Butt. 32, 223-226   DOI   ScienceOn
4 Salem, N. J. and Niebylski, C. D, (1995). The nervous system has an absolute molecular species requirement for proper function. Mot. Membr. Biol. 12, 131-134   DOI   ScienceOn
5 Segura-Aguilar, J. and Lind, C. (1989). On the mechanism of the Mn3+-induced neurotoxicity of dopamine: prevention of quinone-derived oxygen toxicity by DT diaphorasc and superoxide dismutase. Chem. Biol. Interact. 72, 309-324   DOI   ScienceOn
6 Shah, S. V., Cruz, F. C. and Baricos, W. H. (1983). NADPH induced chemiluminescence and lipid peroxidalion in kidney microsome. Kidney Int. 23, 691-698   DOI   ScienceOn
7 Shikano, M., Masuzawa, Y. and Yazawa, K. (1993). Effect of docosabexanoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-l. J. Immunol.15, 3525-3533
8 Simopoulos, A. P. (1991). Omega-3 fatty acids in health and disease and in growth and development. Am. J. Clin. Nutr: 54, 438-463   DOI
9 Hussain, S., Rodgers, D. A., Duhart, H. M. and Ali, S. F. (1997). Mercuric chloride-induced reactive oxygen species and its effect on antioxidanl cnzymes in different regions of rat brain. J. Environ. Sci. Health B 32, 395-409   DOI   ScienceOn
10 Stoll, A. L., Severus, E., Freeman, M. P., Rueter, S., Zboyan, H. A., Diamond, E., Gress, K. K. and Marangell, L. B. (1999). Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, Placebo-controlled trial. Arch. Gen. Psychiatry 56, 413-416
11 Sugiyama, M. (1994). Role of cellular antioxidants in metal induced damage. CeII. Biol. Toxicol. 10, 1-22   DOI   ScienceOn
12 Sun, Y., Oberley, L. W. and Li, Y. (1988). A simple method for clinical assay of superoxide dismutase. Clini. Chem. 34, 497-500
13 Sunderman, F. W., Hopfer, S. M,, Lin, S. M., Plowman, M. C., Stojanovic, T. and Wong, S. H. Y. (1989). Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride. ToxicoI. Appt. Pharmacol. 100, 107-118
14 Urano, S., Sato, Y., Otonari, T., Makabe, S., Susuki, S., Ogata, M. and Endo, T. (1998). Aging and oxidative stress in neurodegeneration. Biofactors 7, 103-112   DOI
15 Vreugdenhil, M., Bruehl, C., Voskuyl, R. A., Kang, J. X., Leaf, A. and Wadman, W. J. (1996). Polyunsaturated fatty acids modulate sodium and calcium currents in CAl neuron. Proc. Natl. Acad. Sci. USA 93, 12559-12563   DOI   ScienceOn
16 Misiewicz, A., Radwan, K., Misiewicz, A. and Dziewit, T. (1999). Malonyl dialdehyde concentration in red blood cells of workers engaged in the production of iron-manganese alloys. Med. Pr. 50,277-281
17 Sloot, W. N., Korf, J., Koster, J. F. and De Wit, L. E. (1996). Gramsbergen JB. Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by doparmine depletion or iron cbelation in vivo. Exp. Neurol. 138, 236-45   DOI   ScienceOn
18 Stajn, A., Zikic, R. V. and Ognjanovic, B. (1997). Effect of cadmium and selenium on the antioxidant defense system in rat kidneys. Comp. Biochem. Physiol. 117, 167-172
19 StilIwell, W., Ehringer, W. and Jenski, L. J. (1993). Docosa-hexanoic acid increases permiability of lipid vesicles and tumor cells. Lipids 28, 103-108   DOI   ScienceOn
20 Youdim, K. A. and Deans, S. G. (1999). Beneficial effects of thyme oil on age-related changes in phospholipid C20 and C22 polyunsturated fatty acid composition of various rat brain. Brit. J. Nutr. 1438, 140-146
21 Billman, G. E., Hallaq, H. and Leaf, A. (1994). Prevention of ischernia-induced ventricular fibrillation by $\omega$3 falty acids. Proc. Natl. Acad. Sci. USA 91, 4427-4430   DOI   ScienceOn
22 Yiin, S. J. and Lin, T. H. (1994). Lipid peroxidation in workers exposed to lead. Arch. Environ. Health 186, 1-17
23 Yiin, S. J., Lin, T. H. and Shin, T. S. (1996). Lipid peroxidation in workers exposed to manganese. Scand. J. Work Environ-Health 22, 381-386   DOI   ScienceOn
24 Bonilla, E.(1980) L-tyrosine hydroxylase activity in the rat brain after chronic oral administration of manganesc chloridc. Neurobehav. Toxicol. 2, 37-41
25 Albert, C. M., Hennekens, C. H., O'Donnell, C. J., Ajani, U. A., Carey, V. J., Willett, W. C., Ruskin, J. N. and Manson, J. E. (1998). Fish consumption and risk of sudden cardiac death. J. Am. Med. Assoc. 279, 23-28   DOI   ScienceOn
26 Archibald, F. S. and Tyree, C. (1987). Manganese poisoning and the attack of trivalent manganese upon catecholamines. Arch. Biochem. Biophys. 256, 638-650   DOI   ScienceOn
27 Barbeau, A. (1984). Manganese and extrapyramidal disorders. Neurotoxicotogy 5, 13-36
28 Benito, S., Fernadez, Y., Mitjavila, S., Moussa, M., Anglade, F. and Periquet, A. (1997). Phospholipid fatty acid Compo-sition affects enzymatic antioxidant defences in cultured Swiss 3T3 fibroblasts. Redox Rep. 3, 281-286   DOI
29 Cramner, J. M. (1998). Report on the fifteenth international neurotoxicology conference. Neurotoxicology 19, 443-445
30 Chandra, S. V., Shukla, G. S. and Srivastava, R. S. (1981). An exploratory study of manganese exposure to welders. CIin.Toxicol. 18, 407-416   DOI
31 Donaldson, W. E. and Knowles, S. 0. (1993). Is lead toxicosis a reflection of altered fatty acid composition of mem-brancs? Comp. Biochem. Physio. 104C, 377-379   DOI
32 Esterbauer, H., Shauer, R. J. and Zollner, H. (1991). Chemistry and biochemistry of 4-hydroxynona1, malondialdehyde and related aldehydes. Free Radic. Biol. Med. 11, 91-128
33 Glozman, S., Green, P. and Yavin, E. (1998). Intraaminiotic ethyl docosahexanoate administratiion protects fetal brain from ischemic stress. J. Neurochem. 70, 2484-2491   DOI
34 Halliwell, B. (1992). Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623   DOI   ScienceOn
35 Halliwell, B. and Gutterige, J. M. C. (1998). Free radicals in biology and rnedicine, Oxford uiiiversity press., Oxford
36 Hibbeln, J. R. (1998). Fish consumplion and major depression. Lancet35l, 1210-1213
37 Huang, C. C., Chu, N. S., Lu, C. S., Chen, R. S. and Calne, D. B. (1998). Long-term progression in chronic manganism: ten years of follow-up. Neurology 50, 698-700   DOI   ScienceOn
38 Hummell, D. S. (1993). Dietary lipids and immune function. Prog. Food Nutr. Sci. 17, 327-329
39 Hurley, L. S. (1981). Teratogcnic aspccts of manganese, zinc, and copper nutrition. PhysioI. Rev. 61, 249-295
40 Knight, J. A. aiid Voorhces, R. P. (1990). Peroxidation of linolenic acid catalysis by transitlion metal ions.AnaI. Clin. Lab. Sci. 20, 347-352
41 Kontur P. J. and Rechter L.D. (1988). Brain regional manganese level and monoamine metabolism in man-ganese-treatetd neonatal rats. NeumtoxicoI. TeratoI. 10, 295-303
42 Lauritzen, I., Blondeau, N., Heurteaux, C., Widmann, C., Romey, G. and Lazdunski, M. (2000). Polyunsaturated fatty acids are potent neuroprotects. EMBO J. 19, 1784-1793   DOI   ScienceOn
43 Lowry 0. H., Rosebrough N. J., Farr A. L. and Randall R. J (1951) Protein measurement with the Folin reagent J. Biol. Chem. 193, 265-275
44 Manca, D., Ricard, A., Trottier, B. and Chevalier, G. (1991). Studies on lipid peroxidation in rat tissues following administration of bow and moderate doses of cadmium chloride. ToxicoIogy 67, 303-323   DOI
45 Markesby, W. R. (1997). Oxidative stress hypothesis in Alzheimer's disease. Free Rad. BioI. Med. 23, 134-147   DOI   ScienceOn
46 Martin, R. E. (1998). Docosahexanoic acid decreases pbospholipase $A_2$, activity in the neuritis/nerve growth cones of PC12 cells. J. Neurosci. Res. 15, 805-13
47 Mason, R. P., Walter, M. F. and Mason, P. E. (1997). Effect of oxidative stress on membrane structure: small angle X-ray diffraction analysis. Free Rad. Biol. Med. 23, 419-425   DOI   ScienceOn
48 Mena, I., Marin, 0., Fuenzalida, S. and Cotzias, G. C. (1967) Chronic manganese poisoning: clinical picture and manganese turnover. Neurology 17, 128-136   DOI
49 Cahie, D. B., Chu, N. S., Huang, C. C., Lu, C. S. and Olanow, W. (1994). Manganism and idiopathic parkinsonism: Simi-larities and differences. Neurology 44, 1583-1586   DOI   ScienceOn