Browse > Article

A STUDY ON THE INFLUENCE OF EPINEPHRINE CONTAINED IN DENTAL LOCAL ANESTHETIC AGENTS ON THE BLOOD SUGAR OF DIABETES DURING MINOR ORAL SURGERY  

Yun, Hyung-Jin (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Korea University)
Rim, Jae-Suk (Dept. of Oral & Maxillofacial Surgery, College of Medicine, Korea University)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.27, no.5, 2005 , pp. 463-471 More about this Journal
Abstract
Recently, the number of diabetic patients have been increased with westernized living way and meal habitation. The regulation of blood sugar concentration is very important for diabetic patients to keep homeostasis and, to prevent acute or chronic complications. Epinephrine combined with lidocaine is used in dental clinic extensively. And epinephrine combined with lidocaine also effects on decreasing the blood leakage volume by constricting micro vessle and arteriole. But, So far there are few researches about the effect of epinephrine contained in dental local anesthetic agent on the blood sugar of diabetes during minor oral surgery. The purpose of this study was intended to investigate whether epinephrine which combined with dental local anesthetics influence body glucose level in diabetes patients by glucose monitoring. The subject of this study were 38 diabetic patients and 38 normal adults, each patient was checked body glucose after a meal 2 hours later with resting state, and injection 1:100000 epinephrine with dental lidocaine 54 ml or lidocaine 54 ml only. And then the body glucose level was checked 5 minutes and 30 minutes after injection. The results were analyzed by two way ANOVA test (p<0.05). The results were as follows: In the experimental group 1, the mean of the blood sugar level was 180.3 mg/dl before an anesthetic injection, 182.8 mg/dl after 5minutes of the anesthetic injection and 182.2 mg/dl after 30minutes of the anesthetic injection. The change of the blood sugar level was not statistically by two-way ANOVA tests (p<0.05). In the experimental group 2, the mean of the blood sugar level was 237 mg/dl before an anesthetic injection, 234.5 mg/dl after 5minutes of the anesthetic injection and 231.8 mg/dl after 30minutes of the anesthetic injection. The change of the blood sugar level was not statistically by two-way ANOVA tests (p<0.05). In the controlled group 1, the mean of the blood sugar level was 117.6 mg/dl before an anesthetic injection, 119.1 mg/dl after 5minutes of the anesthetic injection and 129.3 mg/dl after 30minutes of the anesthetic injection. The change of the blood sugar level was not statistically by two-way ANOVA tests (p<0.05). In the controlled group 2, the mean of the blood sugar level was 104.2 mg/dl before an anesthetic injection, 102 mg/dl after 5minutes of the anesthetic injection and 105.3 mg/dl after 30minutes of the anesthetic injection. The change of the blood sugar level was not statistically by two-way ANOVA tests (p<0.05).
Keywords
Diabetes; Lidocaine; Epinephrine; Blood sugar;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Abouna GM, Al-adnani MS, Kremer GD, et al : Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into non-diabetic recipients. Lancet 2 : 1274, 1983   PUBMED
2 Tolas AG et al : Arterial plasma epinephrine concentrations and hemodynamic response after dental injection of local anesthetic with epinephrine. J Am Dent Assoc 104 : 41, 1982   DOI   PUBMED
3 In-Kyo Jung : Study on the influence of epinephrine contained in dental local anesthetic agents on the blood pressure. Pusan medical univ 22(2) : 443, 1982
4 American Diabetes Association : Role of cardiovascular risk factors in prevention and treatment of macrovascular disease in diabetes. Diabetes care 12 : 573, 1989   DOI   PUBMED
5 Tucker GT, Mather LE : Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 4 : 241, 1979   DOI   ScienceOn
6 Tainter MS, Throndson AH, Moore SM : Vasoconstrictors on the clinical effectivness and toxicity of procaine anesthetic solution. J of ADA and D Cos, 25 : 1321, 1938
7 Hove KA, Stallard RE : Diabetes and the periodontal patient. J Periodontol 41 : 713, 1970   DOI   PUBMED
8 Follmar KE : A study of the effect on blood pressure of epinephrine when in combination with a 2% procaine anesthetic solution. J of ADA 25 : 1321, 1938
9 Klein R : Recent developments in the understanding and management of diabetic retinopathy. Med Clin N Am 72:1415, 1988   DOI
10 Cheraskin E : Use of epinephrine with local anesthesia in hypertensive patients. JADA 56 : 210, 1968
11 Graf RJ, Halter JB, Pfeifer Ma, et al : Glycemic control and nerve conduction abnormalities on non-insulin-dependent diabetic subjects. Ann Int Med 94 : 307, 1981   DOI   ScienceOn
12 Femer Re : Oral hypoglycemic agents. Med Clin North Am 72 : 1329, 1988
13 Heon-Ki Min : Clinical characteristics of Korean diabetic patients. Diabetes 16 : 163, 1992
14 Internal medication of diabetes : Korean Diabetes Association. Korea medical book publisher, Seoul, 2004
15 Catterall W, Mackie K : Local anesthetics. In: Hardman JG, Limbird LE, Molinoff PB, et al : The pharmarcological basis of therapeutic, McGraw-Hill Book 9 : 331, 1996
16 Epstein S : Clinical study of prilocaine with varying concentrations of epinephrine. J Am Dent Assoc 78 : 85, 1969   DOI   PUBMED
17 Follmar KE, Skau RM, Billett AE et al : The effects upon human blood pressure of representative local anesthetics and vasoconstrictors, Northwest Univ, 54 : 13, 1954
18 Byung-Du Lee : Biodynamic specific characteristics of Korean diabetes and prevention of non-insulin dependent diabetes mellitus. J Inje medical uni 67, 1992
19 Bromage PR : Epidural analgesia. W.B Saunders 85, 142, 284, 1978
20 New York Heart Association, Inc: Report of special committee on the use of epinephrine in connection with procaine in dental procedure. JAMA 157 : 854, 1955   DOI
21 Costich ER : A study on inferior alveolar nerve block anesthesia in human comparing 2.0% procanine with 2.0% procaine plus 1:50,000 epinephrine, T. Dent Res 35(5) : 696
22 Brow G : The influence of adrenaline, noradrenaline vasoconstrictors on the effciency of lidocaine. J Oral Ther Pharmacol 4 : 398, 1968   PUBMED
23 Donald A : Systemic effect of dental local anesthetic solution. Oral surg 9 : 1397, 1956
24 Phillips P : Diabetic complications, macrovascular disease. Med progress 13(1) : 13, 1991