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Anti-inflammatory Activity of the Ethanol Extract from Magnoliae Flos on PAR2-mediated Edema  

Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Park, Yeong-Seo (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.13, no.6, 2005 , pp. 245-249 More about this Journal
Abstract
The flower of Magnolia denudata Desrousseaux(Magnoliaceae) has long been used for treatment of nasal disorder in Korea. The physiological activity of the Magnoliae Flos ethanol extract (MFX) was investigated. MFX showed antimicrobial activity. At doses of 100 and 200 mg/kg, MFX showed significant inhibition on both change in paw volume and vascular permeability. MFX (100 mg/kg) significantly inhibited PAR2 agonist-induced myeloperoxidase (MPO) activity in paw tissue. These results indicate that MFX has anti-inflammatory activity in PAR2-mediated paw edema.
Keywords
Magnoliae Flos; Anti-inflammatory; Trypsin; $tc-NH_2$; Paw edema;
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Times Cited By KSCI : 1  (Citation Analysis)
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