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A Synthesis of Alkylphenyl fluorobenzoate Derivatives and Their Antifungal Activities on Several Phytopathogens  

Choi, Won-Sik (Department of Biotechnology, Soonchunhyang University)
Cha, Kyung-Min (Department of Biotechnology, Soonchunhyang University)
Kim, Young-Sun (Department of Biotechnology, Soonchunhyang University)
Jang, Soon-Ho (Department of Biotechnology, Soonchunhyang University)
Lim, Sang-Ho (Namyang Dairy Products Research Institute)
Choi, In-Young (Dongbu Hitec Agrolife Research Institute)
Kim, Tae-Jun (Dongbu Hitec Agrolife Research Institute)
Jung, Bong-Jin (Dongbu Hitec Agrolife Research Institute)
Publication Information
The Korean Journal of Pesticide Science / v.12, no.4, 2008 , pp. 307-314 More about this Journal
Abstract
Sixty compounds such as alkylphenyl fluorobenzoate esters from thymol(I), 5-isopropyl-3-methylphenol (II), 4-isopropyl-3-methylphenol (III), 2-sec-butylphenol (IV) and 4-sec-butylphenol (V) were synthesized. These derivatives were identified by IR, $^1H$-NMR spectrometer and GC/MS. Their in vivo antifungal activities were tested against phytopathogens such as Phytophthora infestans, Botrytis cinerea, Colletotrichum orbiculare and Rhizoctonia solani. As the result, 2-sec-butylphenyl 2,5-difluorobenzoate (IV-6) and 4-sec-butylphenyl 2,5-difluorobenzoate (V-6) showed 90% above antifungal activity against Botrytis cinerea. 2-Isopropyl-5-methylphenyl 2,3,6-trifluorobenzoate (I-11), 2-isopropyl-5-methylphenyl 2,4,5-trifluorobenzoate (I-12), 5-isopropyl-3-methylphenyl 2,3,6-trifluorobenzoate (II-11), 4-isopropyl-3-methylphenyl 2,3,6-trifluorobenzoate (III-11) and 4-isopropyl-3-methylphenyl 2,4,5-trifluorobenzoate (III -12) showed 90% above potent antifungal activity against Colletotrichum orbiculare.
Keywords
Antifungal activity; Botrytis cinerea; Colletotrichum orbiculare; 4-isopropyl-3-methylphenyl 2,3,6-trifluorobenzoate; 2-sec-butylphenyl 2,5-difluorobenzoate;
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Times Cited By KSCI : 6  (Citation Analysis)
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