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Antifungal activities for derivatives of 4-isopropyl-3-methylphenol and 5-isopropyl-3-methylphenol against plant pathogenic fungi  

Choi, Won-Sik (Department of Genetic Engineering, Soonchunhyang University)
Jang, Soon-Ho (Department of Genetic Engineering, Soonchunhyang University)
Jang, Do-Yeon (Department of Genetic Engineering, Soonchunhyang University)
Choi, Kyoung-Gil (Department of Genetic Engineering, Soonchunhyang University)
Lee, Byung-Ho (Dongbu Advanced Research Institute)
Kim, Tae-Jun (Dongbu Advanced Research Institute)
Jung, Bong-Jin (Dongbu Advanced Research Institute)
Publication Information
The Korean Journal of Pesticide Science / v.10, no.4, 2006 , pp. 249-261 More about this Journal
Abstract
Fifty compounds such as ester, sulfonyl ester, carbamate, ether and phosphoyl ester derivatives of 4-isopropyl-3-methylphenol(I) and 5-isopropyl-3-methylphenol(II) were synthesized. These derivatives were identified by IR, GC/MS and $^1H$-NMR spectra. Their in vitro antifungal activities were tested against 10 plant pathogenic fungi. Among them, several compounds showed potent in vitro antifungal activity. The selected compounds showing potent in vitro antifungal activity were tested for their in vivo antifungal activities against 5 plant diseases such as rice blast, rice sheath blast, cucumber anthracnose, cucumber gray mold and tomato late blight. As a result, 4-isopropyl-3-methylphenyl(2-amino-thiazole-4-yl)methoxyiminoacetate(I-7a) showed a potent in vivo antifungal activity against rice blast. Both methyl (4-isopropyl-3-methylphenoxy)acetate(I-4d) and methyl (5-isopropyl-3-methylphenoxy)acetate(II-4d) effectively inhibited the development of cucumber gray mold.
Keywords
4-isopropyl-3-methylphenol; 5-isopropyl-3-methylphenol; Antifungal activity; phytopathgenic fungi;
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Times Cited By KSCI : 1  (Citation Analysis)
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