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In vitro and in vivo antifunal activaties of derivatives of thymol( I ) and carvacrol(II) againt phytopathogenic fungi  

Choi, Won-Sik (Department of Genetic Engineering, Soonchunhyang University)
Jung, Chan-Jin (Department of Genetic Engineering, Soonchunhyang University)
Jang, Do-Yun (Department of Genetic Engineering, Soonchunhyang University)
Cha, Kyoung-Min (Department of Genetic Engineering, Soonchunhyang University)
Um, Dae-Yong (Dongbu Advanced Research Institute)
Kim, Tae-Jun (Dongbu Advanced Research Institute)
Jung, Bong-Jin (Dongbu Advanced Research Institute)
Publication Information
The Korean Journal of Pesticide Science / v.10, no.4, 2006 , pp. 237-248 More about this Journal
Abstract
Forty one compounds such as ester, sulfonyl ester, carbamate, ether and phosphoyl ester derivatives of thymol(I) and carvacrol(II) were synthesized. These derivatives were identified by IR, GC/MS and $^1H$-NMR spectra. Their antifungal activities were tested against various plant pathogenicfugi. Among them, several compounds were showed potent in vivo antifungal activities. The selected compounds showing in vitro antifungal activities were tested in vivo antifungal activities aganint 5 plant diseases such as rice blast, rice sheath blight, tomato late blight, cucumber anthracnose, and cucumber gray mold. As a result, 2-isopropyl-5-methylphenylacetate(I-1a) effectively suppressed the development cucumber gray mold and rice blast. Methyl(2-isopropyl-5-methylphenoxy)acetate(I-6d) and ethyl 4-(5-methyl-2-isopopylphenoxy)crotonate(I-7d) also showed potent in vivo antifungal actively againt rice sheath blight and tomato late blight, respectively.
Keywords
essential oil; thymol; carvacrol; phytophathogenic fungi antifungal activity;
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