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http://dx.doi.org/10.4014/kjmb.1301.01008

Immunomodulatory and Antigenotoxic Properties of Bacillus amyloliquefaciens KU801  

Lee, Na-Kyoung (Division of Animal Life Science and Bio/Molecular Informatics Center, Konkuk University)
Kim, So-Yeon (Division of Animal Life Science and Bio/Molecular Informatics Center, Konkuk University)
Chang, Hyo-Ihl (School of Life Sciences and Biotechnology, Korea University)
Park, Eunju (Department of Food Nutrition, Kyungnam University)
Paik, Hyun-Dong (Division of Animal Life Science and Bio/Molecular Informatics Center, Konkuk University)
Publication Information
Microbiology and Biotechnology Letters / v.41, no.2, 2013 , pp. 249-252 More about this Journal
Abstract
The Bacillus KU801 strain, due to its potential in the field of probiotics for animal use, was isolated from chicken feces. Strain KU801 was identified as Bacillus amyloliquefaciens KU801 based on the results of 16S rRNA sequencing. Vegetative and spore cells of B. amyloliquefaciens KU801 were resistant to artificial gastric juice and artificial bile acid. B. amyloliquefaciens KU801 was found to inhibit the production of nitric oxide (NO) and increase the production of Interleukin-1 alpha (IL-1${\alpha}$). DNA damage induced by N-methyl-Ntion of ninitroso-guanidine (MNNG) was significantly inhibited, in a dose dependent manner, by preincubating MNNG together with B. amyloliquefaciens KU801. These results demonstrate the potential use of B. amyloliquefaciens KU801 as a feed additive.
Keywords
Identification; probiotic; interleukin-1${\alpha}$; nitritic oxide; DNA damage;
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