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Inhibition of Growth and Collagenase Activity of the Extract from Salvia miltiorrhiza against Microorganisms Causing Periodontal Diseases  

민응기 (신화제약(주))
김용해 (신화제약(주)
금상일 (동국대학교 대학원 생물학)
한영환 (동국대학교 자연과학대학 생명과학과)
Publication Information
Korean Journal of Microbiology / v.40, no.2, 2004 , pp. 111-114 More about this Journal
Abstract
This study was carried out to evaluate the inhibition of growth and collagenase activity of Salvia miltiorrhiza Bunge against microorganisms causing periodontal diseases. The ethanol extract of Salvia miltiorrhiza showed sig-nificant growth inhibition against microorganisms causing periodontal diseases. Ethanol extract was further fractionated with organic solvents in the order of hexane, chloroform and ethyl acetate. Among the fractions tested, the hexane fraction showed the highest cell growth inhibition. The minimal inhibitory concentration (MIC) of the extract against C. curvus, C. rectus, E. corrodens, F nucleatum, P. gingivalis, P. intermedia and W. succinogenes were 200, 50, 50, 250, 150, 250 and 200 ${\mu}g$/ml, respectively. The inhibition of collagenase activity by organic solvent fractions were higher than that of minocycline, and the inhibition ratio of collagenase activity was $88.2{\pm}2.1$ % in the chloroform fraction.
Keywords
collagenase; periodontal diseases; Salvia miltiorrhiza;
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Times Cited By KSCI : 2  (Citation Analysis)
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