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http://dx.doi.org/10.5657/KFAS.2022.0867

Chondroprotective Effects of a 30% Ethanol Extract of Sargassum fulvellum  

Jang, Goeun (Marine Healthcare Research & Evaluation Center, Chosun University)
Han, Seul Hee (Marine Healthcare Research & Evaluation Center, Chosun University)
Kim, Do Kyung (Department of Oral Biochemistry, College of Dentistry, Chosun University)
Kim, Chun Sung (Department of Oral Biochemistry, College of Dentistry, Chosun University)
Publication Information
Korean Journal of Fisheries and Aquatic Sciences / v.55, no.6, 2022 , pp. 867-874 More about this Journal
Abstract
Osteoarthritis (OA) is an inflammatory disease due to wear caused by the continuous use of cartilage. Although many drugs for treating OA are being studied, they have side effects, such as digestive disorders and cardiovascular diseases. Glucosamine, a drug derived from natural products, is known to be less effective. Therefore, the marine organism, Sargassum fulvellum, was studied to determine whether it contains substances with a chondroprotective effect on the inflammatory response of chondrocytes induced by interleukin-1β (IL-1β). A 30% ethanol extract of S. fulvellum (SF30%EtOH) has therapeutic and few side effects. We first confirmed the presence of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS), which is expressed during inflammatory reactions. We then examined the expression of collagen type II, which is the main component of the extracellular matrix and cartilage. Finally, the expression of extracellular matrix degrading enzymes, MMPs and ADAMTS-4 and -5, was confirmed. The results showed that SF30%EtOH reduced the expression levels of NO, iNOS, MMPs, and ADAMT-4 and -5, and increased the expression level of collagen type II in chondrocytes induced with IL-1β. Therefore, SF30%EtOH has a chondroprotective effect against inflammation, indicating its potential use for the prevention and treatment of OA.
Keywords
Articular cartilage; Chondroprotective effect; Inflammatory responses; Osteoarthritis; Sargassum fulvellum;
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