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The Growth Inhibitory Effects of Atrina Pecitinata Fractions on Cancer Cell Lines  

Park Soune-Young (Department of Food and Nutrition, Silla University)
Shin Mi-Ok (Department of Food and Nutrition, Silla University)
Lee Sang Hyun (Department of Biotechnology, Silla University)
Bae Song-Ja (Marine Biotechnology Center for Biofunctional Material Industries)
Publication Information
Journal of Nutrition and Health / v.38, no.4, 2005 , pp. 307-312 More about this Journal
Abstract
We investigated the growth inhibitory effects of Atrina pecitinata (AP) on the proliferation in human cancer cell lines in vitro. AP was extracted with methanol which was further fractionated into four different types: methanol (APMM), haxane (APMH), butanol (APMB), and aquous layers (APMA). Among various partition layers, the APMM showed the strongest cytotoxic effects on all cancer cell lines which we used. In the MTT assay of AP fractions, the growth inhibitory effects was increased in proportion to its concentration. We observed quinone reductase (QR) induced effects in all fraction layers of AP on HepG2 cells. The QR induced effects of APMM on HepG2 cell at 80 $\mu$g/mL concentration indicated 2.0 with a control value of 1.0.
Keywords
cytotoxicity; quinone reductase; Atrina pecitinata.;
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