Browse > Article

Effect of Soy Isoflavone Supplementation on Bone Metabolism Marker and Urinary Mineral Excretion in Postmenopausal Women  

이다홍 (숙명여자대학교 식품영양학과)
승정자 (숙명여자대학교 식품영양학과)
Publication Information
Journal of Nutrition and Health / v.36, no.5, 2003 , pp. 476-482 More about this Journal
Abstract
We studied the effects of soy isoflavone supplements on bone metabolism marker (serum osteocalcin, urinary deoxypyridinoline) and urinary mineral excretion (urinary Ca, Mg, Zn) in 47 postmenopausal women. There were 24 participants in the treatment group and 23 in the control group. The treatment group consumed isoflavone extract capsules daily (which contained 90 mg of soy isoflavones) for 12 weeks. The study compared before and after isoflavone intake in the following areas: Physical examination, diet survey, bone metabolism marker and urinary mineral excretion. The average age of the treatment group was 64.6 years and that of the control group was 66.5 years. There were no significant differences between the two groups in terms of height, weight and body mass index. Both groups maintained a regular diet pattern in terms of their average daily nutrient intake. There were no significant differences between the treatment group (23.9 mg) and the control group (25.4 mg) in terms of daily isoflavone intake based on diet. The analysis of bone metabolism marker changes in the treatment group after 12 weeks of taking the isoflavone supplements demonstrated significant differences in the following: Serum osteocalcin (13.7 ng/mL in befor versus 6.8 ng/mL in after) and urinary deoxypyridinoline (5.9 nmol/mmol Cr in befor versus 4.5 nmol/mmol Cr in after). The subjects in the treatment group showed no significant difference in urinary Ca excretion. But the subjects showed a significant difference in urinary Mg (131.9 mg/day in befor versus 115.6 mg/day in after) and Zn (400.5 $\mu\textrm{g}$/day in befor versus 310.2 $\mu\textrm{g}$/day in after) excretion in the isoflavone treatment group at the levels of p<0.001, p<0.01, respectively. No changes were made in the intake of minerals. The composition of serum osteocalcin and urinary deoxypyridinoline, and indicators of bone metabolism, including the excretion Mg and Zn, significantly decreased. As a result, bone mineral loss was lessened. (Korean J Nutrition 36(5): 476~482, 2003)
Keywords
soy isoflavones; serum osteocalcin; urinary deoxypyridinoline; urinary mineral excretion; postmenopausal women;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Estimated isoflavone intake from soy products in Korean middle-aged Women /
[ Lee,S.K.;Lee,M.J.;Yoon,S.;Kwon,D.J. ] / J Korean Soc Food Sci Nutr   과학기술학회마을
2 Derect, enzyme-linked immunoassay for urinary deoxypyridinoline as a spectific marker for measuring bone resorption /
[ Robin,S.P.;Woitge,H.;Hesley,R.(et al.) ] / J Bone & Mineral Research
3 A study on dietary isoflavone intake from soy foods and urinary isoflavone excretion and, menopausal symptoms in Korean Women in Rural areas /
[ Sung,C.J.;Choi,S.H.;Kim,M.H.;Park,M.H.;Ko,B.S.;Kim,H.K. ] / Korean J Community Nutrition   과학기술학회마을
4 Smoking increases bone loss and decreases intestinal calcium absorption /
[ Krall,E.A.;Dawson-Hughes, B. ] / J Bone Miner Res   DOI   ScienceOn
5 /
[ Korea National Statistical Office ] / Complete life Tables
6 Trace mineral status in postmenopausal women:impact of hormonal replacement therapy /
[ Bureau,I.;anderson,R.A.;Arnauud,J.;Raysiguier,Y.;Favier,A.E.;Roussel,A.M. ] / J Trace Elem Biol   DOI   ScienceOn
7 Zinc excretion in osreoporosis women /
[ Herzberg,M.;Foldes,J.;Steinberg,R.;Menczel,J. ] / J Bone Miner Res   DOI   ScienceOn
8 Dose-dependent bone-sparing effects of dietary isoflavones in the ovariectomised rat /
[ Picherit,C.;Chanteranne,B.;Bennetau-pelissero, C.;Davicco,M.J.;Lebecque,P.;Barlet,J.P.;Coxam,V. ] / Br J Nutr   DOI   ScienceOn
9 Total and free deoxypyridinoline after acute osteoclast activity inhibition /
[ Rubinacci,A.;Melzi,R.;Zampino,M.;Soldarini,A.;Villa,I. ] / Clin Chem
10 Soy phytoestrogens and bone /
[ Pansini,F.;Bonaccorsi,G.;Albertazzi,P.;Costantino,D.;Valerio,A.;Negri,C.;Ferrazzini,S.;Bonocuore,I.;De aloysio, D.;Fontana,A.;Pansini,N.;Mollica,G. ] / Annual Meeting of the North American Menopause Society
11 Bone Mass and Markers of bone and calcium metabolism in postmenopausal women treated with 1, 25-Dihydroxyvitamin D (Calcitriol) for Four years /
[ Sairanen,S.;Karkkainen,M.;Tahtela,R.;Laitinen,K.;Makela,P.;Lamberg-Allardt, C.;Valimaki,M.J. ] / Calcif Tissue Int   DOI   ScienceOn
12 Zinc and osteoporosis in patients with spinal cord injury /
[ Ohry,A.;Shemesh,Y.;Zak,R.;Herzberg,M. ] / Paraplegia   DOI   ScienceOn
13 The Role of Phytoestrogens in the Prevention and Treatmant of Osteoporosis in Ovarian Hormone Deficiency /
[ Arjmandi,B.H. ] / J Am Coll Nutr   DOI
14 Zinc, biochemical markers of nutrition, and type I osteoporosis /
[ Relea,P.;Revilla,M.;Ripoll,E.;Arribas,I.;Villa,L.F.;Rico,H. ] / Age Ageing   DOI   ScienceOn
15 Serum bone-gla protein:a specific marker for bone formation in postmenopausal osteoporosis /
[ Brown,J.P.;Delmas,P.D.;Malaval,L.;Edouard,C.;Cahpuy,M.C.;Meunier,P.J. ] / Lancet
16 새로운 약제사용측면에서 본 biochemical marker의 임상적 유용성 /
[ 민용기 ] / '98 골다공증 연수강좌
17 Interaction of estrogenic chemicals and phytoestrogen receptor /
[ Kuiper,G.;Lemmen,J.;Carlsson,B.(et al.) ] / β. Endocrinology   DOI   ScienceOn
18 Biochemical markers of bone remodeling /
[ Kleerekoper,M. ] / Am J Med Sci   DOI   ScienceOn
19 Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats /
[ Picherit,C.;Coxam,V.;Bennetau-Pelissero, C.;Kati-Coulibaly, S.;Davicco,M.;Lebecque,P.;Barlet,J. ] / J Nutr
20 Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women:A four-week study /
[ Uesugi,T.;Fukui,Y.;Yamori,Y. ] / Original research
21 Soy consumption and potential benefits for bone and heart health in the Chinese population /
[ Ho,S.C. ] / 8th Asian Congress of Nutrition
22 Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture /
[ Liu,G.;Peacock,M. ] / Caicif Tissue Int   DOI   ScienceOn
23 Isoflavone levels in soy foods consumed by multiethnic populations in Singapore and Hawaii /
[ Franke,A.A.;Hankin,J.H.;Yu,M.C.;Maskarinec,G.;Low,S.H.;Custer,L.J. ] / J Agric Food Chem   DOI   ScienceOn
24 Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women /
[ Szulc,P.;Arlot,M.;Chapuy,M.C.;Duboeuf,F.;Meunier,P.J.;Delmas,P.D. ] / J Bone Miner Res   DOI   ScienceOn
25 Soyfoods, soybean isoflavones, and bone health /
[ Messina,M. ] / KOREA SOYBEAN SOCIETY ISSN
26 Marked diurnal variation in urinary excretion of pyridinium crosslinks in premenopausal women /
[ Schlemmer,A.;Hassager,C.;Jensen,S.B.;Christiansen,C. ] / J Clin Endocrinol Metab   DOI
27 Changes in bone turnover and deoxypyridinoline levels in epileptic patients /
[ Telci,A.;Cakatay,U.;Kurt,B.B.;Kayali,R.;Sivas,A.;Akcay,T.;Gokyigit,A. ] / Clin Chem Lab Med   DOI   ScienceOn
28 Phytoestrogens:the biochemistry, physiology,and implications for human health of soy isoflavones /
[ Setchell,K.D.R. ] / Am J Clin Nutr
29 /
[ Lee,G.N.;Mun,H.R.;Lee,E.H. ] / Lab test 2000 directory
30 Hormone replacement therapy increases serum 1, 25-dihydroxyvitamin D;A 2-year prospective study /
[ van Hoof, H.J.;van der Mooren, M.J.;Swinkels,L.M.;Rolland,R.;Benraad,T.J. ] / Calcif Tissue Int   DOI   ScienceOn
31 /
[ Gibson,R.S. ] / Principles of Nutritional Assessment
32 Soy protein and isflavones:their effects on blood lipids and bone density in postmenoapusal women /
[ Potter,S.M.;Baum,J.A.;Teng,H.;Stillman,R.J.;Shay,N.F.;Erdman,J.R. J.W. ] / Am J Clin Nutr
33 A comparative study on biochemical markers of collagen breakdown in postmenopausal women /
[ Sirtori,P.;Sosio,C.;Polo,R.M.;Tenni,R.;Rubinacci,A. ] / Pharmacol Res   DOI   ScienceOn
34 /
[ Baek,S.K. ] / A study of soy isoflavone supplementation effect on bone mineral density and bone metabolism markers in female college students with low bone mass
35 Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women:a randomized double blind placebo-controlled study /
[ Morabito,N.;Crisafulli,A.;Vergara,C.;Gaudio,A.;Lasco,A.;Frisina,N.;D'Anna, R.;Corrado,F.;Pizzoleo,M.A.;Cincotta,M.;Altavilla,D.;Lentile,R.;Squadrito,F. ] / J Bone Miner Res   DOI   ScienceOn
36 Metabolic and bone effects after administration of ipriflavone and salmon calcitonin in postmenopausal osteoporosis /
[ Cecchettin,M.;Bellometti,S.;Cremonesi,G.;Solimeno,L.P.;Torri,G. ] / Biomed & Pharmacother   DOI   ScienceOn
37 Evidence for involvement of 17 β-estradiol in intestinal calcium absorption independent of 1, 25-dihydroxyvitamin D3 levels in the Rat /
[ Colin ,E.M.;Van Den Bend, G.J.;Van Aken, M.;Christakos,S.;Dejonge,H.R.;Deluca,H.F.;Prahl,J.M.;Birkenhager,J.C.;Buurman,C.J.;Pols,H.A.;Van Leeuwen, J.P. ] / J Bone Miner Res   DOI   ScienceOn
38 Phytoestrogens in the management of the menopause:up-to-date /
[ Ewies,A.A. ] / Obstet Gynecol Sury   DOI   ScienceOn
39 Computer Aided Nutritional Analysis Program for Professionals /
[] / The Korean Journal of Nutrition
40 Japanese intake of flavonoids and isoflavonoids from foods /
[ Kimira,M.;Arai,Y.;Shimoi,K.;Watanabe,S. ] / J Epidemiol   DOI   ScienceOn
41 Isoflavones:Souce and metabolism. Hanbook of nutraceuticals and functional foods /
[ Hendrich,S.;Murphy,P.A.;Wildman,R.E.C.(ed.) ] / FL:CRC Series in Modern Nutrition
42 Zinc excretion in oseroporosis women /
[ Szathmari,M.;Steczek,K.;Szucs,J.;Hollo,I. ] / Orv Hetil
43 Osteocalcin:Diagnostic Methods and clinical application /
[ Power,M.J.(et al.) ] / Clin Lab Sciences   DOI   ScienceOn
44 Growth hormone and sex steroid effects on bone metabolism and bone mineral density in healthy aged women and men /
[ Christmas,C.;O'Connor, K.G.;Harman,S.M.;Tobin,J.D.;Munzer,T.;Bellantioni,M.F.;Clair,C.S.;Pabst,K.M.;Sorkin,J.D.;Blackman,M.R. ] / J Gerontol a Biol Sci Med Sci   DOI
45 Estrogen regulation of intestinal calcium absorption in the intact and ovariectomized adult rat /
[ Ten Bolscher, M.;netelenbos,J.C.;Barto,R.;Van Buuren, L.M.;vander vijgh, W.J. ] / J Bone Miner Res   DOI   ScienceOn
46 responses of biochemical markers of bone turnover to hormone replacement therapy:impact of biological variability /
[ Gennari,C.;Adami,S.;Naylor,K.;Eastell,R. ] / J Bone Miner Res
47 The effect of estrogen replacement therapy on zinc in serum and urine /
[ Herzberg,M.;lusky,A.;Blonder,J.;Frenkel,Y. ] / Obstetrics & Gynecology   DOI   ScienceOn