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http://dx.doi.org/10.13104/jksmrm.2014.18.1.52

Development of $^1H-^{31}P$ Animal RF Coil for pH Measurement Using a Clinical MR Scanner  

Kim, Eun Ju (Department of Radiology, Severance Hospital, YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine)
Kim, Daehong (Molecular Imaging & Therapy Branch, National Cancer Center)
Lee, Sangwoo (GE Healthcare. Global Applied Science Laboratory)
Heo, Dan (Department of Radiology, Severance Hospital, Yonsei University College of Medicine)
Lee, Young Han (Department of Radiology, Severance Hospital, YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine)
Suh, Jin-Suck (Department of Radiology, Severance Hospital, YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine)
Publication Information
Investigative Magnetic Resonance Imaging / v.18, no.1, 2014 , pp. 52-58 More about this Journal
Abstract
Purpose : To establish a pH measurement system for a mouse tumor study using a clinical scanner, to develop the $^1H$ and 31P radio frequency (RF) coil system and to test pH accuracy with phantoms. Materials and Methods: The $^1H$ and the $^{31}P$ surface coils were designed to acquire signals from mouse tumors. Two coils were positioned orthogonally for geometric decoupling. The pH values of various pH phantoms were calculated using the $^1H$ decoupled $^{31}P$ MR spectrum with the Henderson-Hasselbalch equation. The calculated pH value was compared to that of a pH meter. Results: The mutual coil coupling was shown in a standard $S_{12}$. Coil coupling ($S_{12}$) were -73.0 and -62.3 dB respectively. The signal-to-noise ratio (SNR) obtained from the homogeneous phantom $^1H$ image was greater than 300. The high resolution in vivo mice images were acquired using a $^{31}P$-decoupled $^1H$ coil. The pH values calculated from the $^1H$-decoupled $^{31}P$ spectrum correlated well with the values measured by pH meter ($R^2$=0.97). Conclusion: Accurate pH values can be acquired using a $^1H$-decoupled $^{31}P$ RF coil with a clinical scanner. This two-surface coil system could be applied to other nuclear MRS or MRI.
Keywords
pH; $^1H-^{31}P$ MR coil; mouse; clinical MR;
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