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http://dx.doi.org/10.13104/jksmrm.2013.17.3.215

The Effect of Gd-EOB-DPTA on the Stiffness Value of Magnetic Resonance Elastography in Evaluating Hepatic Fibrosis  

Lee, Jeong Eun (Department of Radiology, Chungnam National University Hospital)
Lee, Jeong Min (Department of Radiology, College of Medicine Seoul National University)
Lee, Ye Ji (Department of Radiology, College of Medicine Seoul National University)
Yoon, Jeong-Hee (Department of Radiology, College of Medicine Seoul National University)
Lee, Kyung Bun (Department of Pathology, Seoul National University Hospital)
Han, Joon Koo (Department of Radiology, College of Medicine Seoul National University)
Choi, Byung Ihn (Department of Radiology, College of Medicine Seoul National University)
Publication Information
Investigative Magnetic Resonance Imaging / v.17, no.3, 2013 , pp. 215-223 More about this Journal
Abstract
Purpose : To evaluate the effect of gadoxetic acid on the measurement of the stiffness value of MR elastography (MRE) used to evaluate hepatic fibrosis (HF). Materials and Methods: MRE was obtained in 32 patients with clinically suspected chronic liver disease, both before and after injection of gadoxetic acid. Two independent reviewers measured the stiffness values of the liver parenchyma on elastograms. The mean liver stiffness values were compared in the pre- and post-contrast MREs using the paired t-test. Intra-rater and inter-rater correlation was assessed using the intraclass correlation coefficient (ICC). The accuracy, sensitivity, and specificity of both pre- and post-contrast MREs was evaluated for the diagnosis of significant HF (${\geq}F2$) using cut off value of 3.1 kPa. Results: There were no significant differences in the stiffness values of the liver parenchyma on pre- and post-contrast MREs (p = 0.15 and 0.38 for each reader, respectively). Regarding intra-rater correlation, excellent agreement was noted on rater 1(ICC = 0.998) and rater 2 (ICC = 0.996). Excellent correlation regarding the measured stiffness values was noted on both pre- and post-contrast MREs (ICC = 0.988 for pre-contrast, ICC = 0.993 for post-contrast). The accuracy, sensitivity, and specificity of the pre- and post-contrast MREs for differentiating significant HF (${\geq}F2$) from ${\geq}F1$ were same as 71%, 60%, and 100%, respectively. Conclusion: As there was no significant difference in the stiffness measurements seen on MREs before and after administration of gadoxetic acids, it is therefore acceptable to perform MRE after contrast injection in order to evaluate HF.
Keywords
Chronic liver disease; Hepatic fibrosis; MR elastogaphy; Gadoxetic acid; Stiffness value;
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