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Preparation and Characterization of Poly[3-hydroxybutyrate-co-4-hydroxybutyrate] Microsphere  

Kang, Hye-Su (Department of Chemical Engineering, College of Engineering, Chungbuk National University)
Kim, Beom-Soo (Department of Chemical Engineering, College of Engineering, Chungbuk National University)
Publication Information
KSBB Journal / v.22, no.3, 2007 , pp. 146-150 More about this Journal
Abstract
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] microspheres were prepared using solvent evaporation technique. P(3HB-co-4HB) with 3.9 mol% 4HB was synthesized by fed-batch culture of Ralstonia eutropha. The effects of concentration and type of surfactant (Tween 80, sodium dodecylsulfate, and polyvinyl alcohol), addition of dispersion stabilizer (Acacia), concentration of polymer and model drug (bovine serum albumin) on particle size of the microspheres and their in vitro drug release characteristics were investigated. The average particle size of the microspheres decreased with the addition of dispersion stabilizer and increased with the concentration of surfactant, drug and polymer. Amount of drug release increased with decreasing particle size of the microspheres.
Keywords
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate); P(3HB-co-4HB); microsphere; solvent evaporation technique; biodegradable polymer;
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