Browse > Article

Anti-diabetic Effect of the Methanolic Extract of Ligularia stenocephala Leaves in the Streptozotocin-induced Rat  

Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Kim, Won-Bae (National Institute of Highland Agriculture, RDA)
Nam, Jung-Hwan (National Institute of Highland Agriculture, RDA)
Park, Hee-Juhn (Department of Botanical Resources, Sangji University)
Publication Information
Korean Journal of Plant Resources / v.20, no.4, 2007 , pp. 362-366 More about this Journal
Abstract
The leaves of Ligularia stenocephala (Compositae) are used as a vegetable food to treat anxiety, weakness and menstrual disorder and are said to be effective against diabetic disease in Korea. This research was aimed to develop this vegetable food as a functional food to treat diabetic disease. Oral administration of MeOH extract exhibited significant hypoglycemic and hypolipidemic effects in streptozotocin (STZ)-induced diabetic rats at 100 and 200 mg/kg dose. This extract inhibited the increase of body weight, water consumption, food intake, blood glucose, lowered atherogenic index, and overcome glucose intolerance in the STZ-treated rat. These results suggest that the leaves of Ligularia stenocephala could be developed as a functional food with anti-diabetic effect.
Keywords
Ligularia stenocephala; Compositae; Diabetic; Functional food; Vegetable;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Choi, J., J.K. Park, K.T. Lee, K.K. Park, W.B. Kim, J.H Lee, H.J. Jung and H.J. Park. 2004. Inhibitory Effect of Ligularia fischeri var. spiciformis and its Active Component, 3,4-Dicaffeoylquinic acid on the Hepatic Lipid Peroxidation in Acetaminophen-Treated Rat. Nat. Prod. Sci. 10: 182-189   과학기술학회마을
2 Choi, J., J.K. Park, K.T. Lee, K.K. Park, W.B. Kim, J.H. Lee, H.J Jung and H.J Park. 2005. In vivo antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid. J. Med. Food 8: 348-352   DOI   ScienceOn
3 Noma, A.,K. Nezu-Nakayama, M. Kita and H. Okabe. 1978. H Simultaneous determination of serum cholesterol in high- and lowdensity lipoproteins with use of heparin. $Ca^{2+}$, and an anion-exchange resin. Clin. Chem. 24: 1504-1508
4 Steinberg, D. 1997. Oxidative modification of LDL and atherogenesis. Circulation 95: 1062-1071   DOI   ScienceOn
5 Yan, F.L., A.X. Wang and Z.J. Jia. 2005. Three new isopropenyl benzofurans from Ligularia stenocephala. Pharmazie 60: 155-159
6 Miller, N.E. 1978. The evidence for the antiatherogenicity of high density lipoprotein in man. Lipid. 13: 914-919   DOI
7 Kim, T.J. 1996. Korean Reources Plants, The Publishing Center of Seoul National University, Seoul pp. 242-243
8 Richmond, W. 1976. Use of cholesterol oxidase for assay of total and free cholesterol in serum by continuous flow analysis. Clin. Chem. 22: 1579-1588
9 Park, H.J., S.H. Kwon, K.O. Yoo, I.C. Sohn, K.T. Lee and H.K. Lee. 2000. Sesquiterpenes from the leaves of Ligularia fischeri var. spiciformis. Planta Med. 66: 783-784   DOI   ScienceOn
10 Jeong, S.H., S.J. Koo, J. Choi, H.J. Park, J. Ha and K.T. Lee. 2002. Intermedeol isolated from the leaves of Ligularia fischeri var. spiciformis induces the differentiation of human acute promyeolocytic leukemia HL-60 cells. Planta Med. 68: 881-885   DOI   ScienceOn
11 Wang, W.S., K. Gao and Z.J. Jia. 2000. Eremophilenolides from Ligularia fischeri. Planta Med. 66: 189-191   DOI
12 Hwang, B.Y., J.H. Lee, T.H. Koo, Y.S. Hog, J.S. Ro, K.S. Lee and J.J. Lee. 2002. Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Planta Med. 68: 101-105   DOI   ScienceOn
13 Lee, K.T., S.J. Koo, S.H. Jung, J. Choi, H.J. Jung and H.J. Park. 2002. Structure of three new terpenoids, spiciformisins a and b, and monocyclosqualene, isolated from the herbs of Ligularia fischeri var. spiciformis and cytotoxicity. Arch. Pharm. Res. 25: 820-823   DOI   ScienceOn
14 Toyoda, K., Y. Yaoita and M. Kikuchi. 2005. Three new dimeric benzofuran derivatives from the roots of Ligularia stenocephala Matsum. Et Koidz. Chem. Pharm. Bull. 53: 1555-1558   DOI   ScienceOn
15 Ko, K.S. and E.S. Jeon. 2003. Ferns, Fern-Allies and Seed-bearing Plants of Korea, Iljin-Sa, Seoul pp. 680-681
16 Friedewald, W.T., R.I. Levy and D.S. Fredrickson. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 24: 499- 502
17 McGowan, M.W., J.D. Artiss, D.R. Strandbergh and B. Zak. 1983. A peroxidase-coupled method for the colorimetric determination of serum triglycerides. Clin. Chem. 29: 538-542
18 Choi, E.M. 2007. Ligularia fischeri leaf extract prevents the oxidative streee in DBA/1J mice with type II collage-induced arthritis. Journal of Applied Toxicology 10: ahead of print