Browse > Article
http://dx.doi.org/10.6564/JKMRS.2017.21.4.145

Structure Determination of Four Compounds Isolating from Rhizomes of Rhodiola rosea using NMR Spectrometer  

Kim, Yun Na (Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Lee, Jae Sun (Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Kim, Chul Ho (Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology)
Jeong, Eun Ju (Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology)
Publication Information
Journal of the Korean Magnetic Resonance Society / v.21, no.4, 2017 , pp. 145-151 More about this Journal
Abstract
Rhodiola rosea, also known as gold root or rose root, is a perennial plant in the family of Crassulaceae. The rhizhome of R. rosea has been widely used as a hemostatic, tonic for burns and contusions in traditional Chinese medicine. Recent studies reported its strong antioxidant and adaptogenic properties. In this paper, we attempted to isolate compounds from the methanolic extract of R. rosea rhizomes. Four compounds including one new compound (1), two kaempferol glycosides (3 and 4) were isolated from chloroform and ethyl acetate soluble fraction of R. rosea extract. The structures of 1~4 including relative stereochemistry were determined by MS and NMR analysis.
Keywords
Rhodiola rosea; constituents; flavonoid; 1D and 2D NMR;
Citations & Related Records
연도 인용수 순위
  • Reference
1 R. P. Brown, P. L. Gerbarg, and Z. Ramazanov, Herbalgram. 56, 40 (2002)
2 K. De Bock, B. O. Eijnde, M. Ramaekers, and P. Hespel, Int. J. Sport. Nutr. Exerc. Metab. 14, 298 (2004)   DOI
3 S. Platikanov and L. Evstatieva, Econ. Bot. 62, 621 (2008)   DOI
4 A. P. P. Adaptogen, Altern. Med. Rev. 6, 293 (2011)
5 H. Li, S. Sze, Y. Tong, and T. Ng, J. Ethnopharmacol. 123, 257 (2009)   DOI
6 J. Jurica and T. Koupa, Ceska. Slov. Farm. 65, 87 (2016)
7 V. Darbinyan, A, Kteyan, A. Panossian., E. Gabrielian, G. Wikman , and H. Wagner, Phytomedicine 7, 365 (2000)   DOI
8 V. A. Shevtsov, B. I. Zholus, V. I. Shervarly, V. B. Vol'skij, Y. P. Korovin, M. P. Khristich, N. A. Roslyakova, and G.. Wikman, Phytomedicine 10, 95 (2003)   DOI
9 A. A. Spasov, G. K. Wikman, V. B. Mandrikov, I. A. Mironova I. A., and V. V. Neumoin, Phytomedicine 7, 85 (2000)   DOI
10 D. Edwards, A. Heufelder, and A. Zimmermann, Phytother. Res. 26, 1220 (2012)   DOI
11 Q. Zhou, Z. P. Yin, L. Ma, W. Zhao., H. W. Hao, and H. L. Li, Nat. Prod. Res. 28, 2301 (2014)   DOI
12 Z. Ramazanov, National Bioscience Corporation (2002)
13 A. A. Ahmed, M. E. Hegazy, N. M. Hassan, M. Wojcinska, J. Karchesy, P. W. Pare, and T. J. Mabry, Phytochemisrty 67, 1547 (2006)   DOI
14 M. D. Alaniya, M. G. Sutiashvili, N. Sh. Kavtaradze, and A.V. Skhirtladze, Chem. Nat. Compd. 53, 1202 (2017)   DOI
15 C. Y. Liu, D. N. Xie, L. L. An, Z. J. Li, C. L. Si, Y. S. Bae, G.. Xu, and L. Wu, Chem. Nat. Compd. 53, 1020 (2017)   DOI