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http://dx.doi.org/10.5012/bkcs.2014.35.6.1625

Three Component Solvent-free Synthesis of Chroman-2,4-dione-based Heterocyclic Ketene Aminal (HKA) Derivatives by "GAP" Chemistry  

Yu, Fu-Chao (Faculty of Life Science and Technology, Kunming University of Science and Technology)
Hao, Xiao-Pan (Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University)
Jiang, Xiu-Yang (Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University)
Yan, Sheng-Jiao (Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University)
Lin, Jun (Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry Education, School of Chemical Science and Technology, Yunnan University)
Publication Information
Bulletin of the Korean Chemical Society / v.35, no.6, 2014 , pp. 1625-1632 More about this Journal
Abstract
A concise and efficient one-pot synthesis of chroman-2,4-dione-based HKA derivatives by three component reaction of HKAs, triethoxymethane and 4-hydroxycoumarin derivatives under solvent-free and catalyst-free conditions is described. This protocol has many advantages, in that the GAP (Group-Assistant-Purification) chemistry process is involved in this method. As a result, the experimenter can avoid cumbersome process steps such as traditional chromatography and recrystallization purifications. The desired products can be easily obtained by washing the crude products with 95% EtOH.
Keywords
GAP chemistry; Heterocyclic ketene aminals (HKAs); 4-Hydroxycoumarin; Chroman-2,4-dione;
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