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http://dx.doi.org/10.5012/bkcs.2011.32.2.656

Silica Gel-Supported Polyphosphoric Acid (PPA-SiO₂) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction

Zeinali-Dastmalbaf, Mohsen (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Davoodnia, Abolghasem (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Heravi, Majid M. (Department of Chemistry, School of Sciences, Azzahra University)
Tavakoli-Hoseini, Niloofar (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Khojastehnezhad, Amir (Department of Chemistry, Faculty of Sciences, Mashhad Branch, Islamic Azad University)
Zamani, Hassan Ali (Department of Applied Chemistry, Quchan Branch, Islamic Azad University)

Publication Information

Bulletin of the Korean Chemical Society / v.32, no.2, 2011 , pp. 656-658 More about this Journal

Abstract

A green and efficient method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones through one-pot three-component reaction of ethyl acetoacetate, an aryl aldehyde, and urea or thiourea in acetonitrile using silica gel-supported polyphosphoric acid (PPA- $SiO_2$ ) as catalyst is described. Compared to the classical Biginelli reaction conditions, the present methodology offers several advantages such as high yields, relatively short reaction times, mild reaction condition and a recyclable catalyst with a very easy work up.

Keywords

Biginelli reaction; Heterogeneous catalysis; PPA- $SiO_2$ ; Multi-component reactions;

Citations & Related Records

Times Cited By Web Of Science : 20 (Related Records In Web of Science)
Times Cited By SCOPUS : 14

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Reference
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1	/ Bulletin of the Korean Chemical Society
2	/ Bulletin of the Korean Chemical Society
3	/ Chinese Journal of Chemistry
4	/ Chemical Papers
5	/ Arkivoc
6	/ Journal of Molecular Liquids
7	/ Oriental Journal of Chemistry
8	/ Bulletin of the Korean Chemical Society

KSCI

Silica Gel-Supported Polyphosphoric Acid (PPA-SiO2) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction

Silica Gel-Supported Polyphosphoric Acid (PPA-SiO₂) Catalyzed One-Pot Multi-Component Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and -thiones: An Efficient Method for the Biginelli Reaction