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Effects of Mountain Ginseng-added High Fat diet on Lipid Peroxidation and Antioxidant Protein Expression of Skeletal Muscle in Rats  

Kwon, Dae-Keun (Division of Sports Science, Sunmoon University)
Kang, Jun-Yong (Division of Sports Science, Sunmoon University)
Song, Youngju (Division of Sports Science, Sunmoon University)
Kim, Pan-Gi (School of Ecological & Environmental Systems, Kyungpook National University)
Seo, Hyobin (Department of Leisure Sports, Kyungpook National University)
Ryu, Sungpil (Department of Leisure Sports, Kyungpook National University)
Publication Information
Journal of Korean Society of Forest Science / v.101, no.1, 2012 , pp. 69-76 More about this Journal
Abstract
We investigated the effect of mountain ginseng-added high fat diet supplementation on lipid peroxidation and antioxidant protein expressions in rats. Thirty-two male rats were randomly divided into 4 groups; HS (high-fat diet sedentary group, n=8), MG1 (0.5% mountain ginseng-added diet group, n=8), MG2 (1% mountain ginsengadded diet group, n=8) and MG3 (2% mountain ginseng-added diet group, n=8). They have fed the diet for 4 weeks. The blood triglyceride were significantly lower in the MG1 and MG2 groups than that of the HS group. The blood HDL-cholesterol were significantly higher in the MG3 group than that of the HS and MG2 groups. The muscle glycogen contents of the MG2 and MG3 groups were significantly higher than that of HS and MG1 groups. The MDA contents in the MG1, MG2 and MG3 groups tended to lower than the HS group. The GPx protein expression in the gastrocnemius muscle of the MG2 group was significantly increased compared to that of the HS group. The Cu,Zn-SOD protein expression in the gastrocnemius muscle of the MG1 and MG2 groups was significantly increased compared to that of the MG3 group. The Mn-SOD protein expression in the MG1, MG2 and MG3 groups tended to higher than the HS group. From these results, it was suggested that mountain ginseng-added diet may have an crucial role on decreased MDA levels and increased antioxidant function in the skeletal muscle of rat fed a high fat diet.
Keywords
mountain ginseng; MDA; GPx protein; SOD protein expression; rat;
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