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http://dx.doi.org/10.13048/jkm.21012

Anti-inflammatory Effects of Ojeok-san in LPS-induced Inflammatory Rat Model  

Kim, Joo-Hee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University)
Lee, Dong Hyuk (College of Korean Medicine, Sangji University)
Kim, Ji Hye (National Development Institute of Korean Medicine)
Jung, Sung Eun (National Development Institute of Korean Medicine)
Ham, Seong Ho (National Development Institute of Korean Medicine)
Yang, Woong Mo (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University)
Kwon, Bo-in (Department of Pathology, College of Korean Medicine, Sangji University)
Publication Information
The Journal of Korean Medicine / v.42, no.2, 2021 , pp. 21-30 More about this Journal
Abstract
Objectives: The aim of this study is to investigate the anti-inflammatory effects of Ojeok-san and compare the therapeutic effects according to its formation. Methods: We evaluated the anti-inflammatory effects of Ojeok-san using lipopolysaccharide (LPS) induced inflammatory animal model. Male SD rats were administered intra-orally with two different formulation types of Ojeok-san according to prescribed dosage. One hour later, to induce inflammatory responses, subsequent intra-peritoneal injection of LPS was conducted. After 5 hours later, serum TNF-α, IL-1β, IL-6 and PGE2 levels were measured by ELISA to assess the alteration of pro-inflammatory markers. Results: In our experiment, regardless of its formation, administration of Ojeok-san decreased TNF-𝛼, IL-1𝛽, IL-6 and PGE2 level in serum. Furthermore, LPS-induced toxicity of liver and kidney was not detected by Ojeok-san administration. Conclusions: The anti-inflammatory effect of Ojeok-san was shown in LPS-induced inflammatory model by decreasing pro-inflammatory markers, and there would be no significant difference in therapeutic effect between two formulation types of Ojeok-san.
Keywords
Ojeok-san; lipopolysaccharide(LPS)-induced model; anti-inflammatory effect; pro-inflammatory markers;
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Times Cited By KSCI : 2  (Citation Analysis)
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