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Analysis of Recent Clinical Studies to Establish Korean Herbal Medicine Clinical Trial Guidelines for the Common Cold  

Kim, Kwan-il (Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Lee, Ho-jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Jung, Hee-jae (Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Jung, Sung-ki (Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung-Hee University)
Lee, Jun-hee (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Publication Information
The Journal of Internal Korean Medicine / v.37, no.1, 2016 , pp. 109-134 More about this Journal
Abstract
Objectives: The aim of this study was to help develop a guideline for the common cold. We searched recent clinical studies of the common cold in Western medicine and reviewed their objectives, inclusion and exclusion criteria, primary outcome, secondary outcome, and assessment tools to establish evidenced-based guideline.Methods: We searched electronic databases (Cochrane Library, MEDLINE, EMBASE) to identify eligible randomized controlled trials (RCTs) about the common cold for the last 10 years. We included 29 RCTs and showed their research summary via their objectives, participants, interventions, control, treatment duration, and results. We also analyzed the definition of the common cold presented in the article, inclusion and exclusion criteria, primary and secondary outcomes, and assessment tools.Results: We reported the aforementioned areas in detail. At first, the definition of the common cold was confused across the articles. Second, herbal medication clinical trials for the common cold have been extensively studied recently. Third, the eligibility criteria frequently included the Jackson Symptom score. Fourth, validated assessment tools (i.e., the Wisconsin Upper Respiratory Symptom Survey-21) have only been used in a few recent studies.Conclusions: Our research will be helpful to establish Korean herbal medicine clinical trial guidelines for the common cold.
Keywords
common cold; randomized controlled trial; review;
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