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Anti-inflammatory Effect of Jakyakgamcho-tang  

Kim, Byoung-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Sang-Ji University)
Publication Information
The Journal of Internal Korean Medicine / v.31, no.2, 2010 , pp. 365-371 More about this Journal
Abstract
The present study investigated the anti-inflammatory effect of Jakyakgamcho-tang in lipopolysaccharide-exposed rats. The plasma concentration of IL-$1\beta$, IL-6 and TNF-$\alpha$ peaked at 5hrs after LPS injection, and these values of the 300 mg/kg Jakyakgamcho-tang group were lower than those of the control group. The plasma concentration of IL-10 peaked at 5hrs after LPS injection and the values of the Jakyakgamcho-tang groups were higher than those of the control group. In the liver cytokines measurement was done at 5hrs after LPS injection. The concentrations of liver IL-$1\beta$ and IL-6 in the 300 mg/kg Jakyakgamcho-tang were lower than that of the control group. The concentrations of liver TNF-$\alpha$, and IL-10 showed no significant differences among all the treatment groups. These results indicate that the Jakyakgamcho-tang has anti-inflammatory activities.
Keywords
Jakyakgamcho-tang; Lipopolysaccharide(LPS); Cytokines; Inflammatory effect;
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