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http://dx.doi.org/10.5658/WOOD.2014.42.5.579

Inhibitory Effects of Camellia sinensis Extract on the Development of Atopic Dermatitis-like Lesions in NC/Nga Mice  

Kim, Tae Hong (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University)
Ha, Si Young (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University)
Yang, Jae-Kyung (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University)
Publication Information
Journal of the Korean Wood Science and Technology / v.42, no.5, 2014 , pp. 579-589 More about this Journal
Abstract
Atopic dermatitis (AD) syndrome is one of the most common and severe skin diseases in Korea; a large population has this disease. We examined the effects of the extract from the leaf and sprig of Camellia sinensis on the development of AD by using NC mice as a model of atopic dermatitis. Oral administration of the extract to NC/Nga mice treated with 2,4?dinitrochlorobenzene (DNCB) inhibited the development of AD-like skin lesions as shown by a significant decrease in the skin symptoms of the disease and a decrease in ear thickness and levels of immunoglobulin E (IgE) and thymus-and activation-regulated chemokine (TARC) level in the skin. Administration of the extract markedly suppressed the DNCB-induced mRNA expression of interleukin 4 (IL-4) and tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$). The findings suggest that transdermal application of the extract may modulate in the skin of NC/Nga mice. The extract was effective for the prevention and treatment of AD.
Keywords
atopic dermatitis; NC/Nga mice; IgE; Camellia sinensis;
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